Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 50873
  • Symbol: Prkn
  • Description: parkin RBR E3 ubiquitin protein ligase

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
50873 GO:0000423 IGI acts_upstream_of_or_within mitophagy 24949970 Process
50873 GO:0001963 IMP acts_upstream_of_or_within synaptic transmission, dopaminergic 12915482 Process
50873 GO:0001964 IMP acts_upstream_of_or_within startle response 15249681 Process
50873 GO:0007612 IMP NOT acts_upstream_of_or_within learning 15684050 Process
50873 GO:0007612 IMP acts_upstream_of_or_within learning 12915482 Process
50873 GO:0007626 IMP NOT acts_upstream_of_or_within locomotory behavior 15684050 Process
50873 GO:0007626 IMP acts_upstream_of_or_within locomotory behavior 12915482,12930822,15882845 Process
50873 GO:0008344 IMP acts_upstream_of_or_within adult locomotory behavior 18346797 Process
50873 GO:0019538 IMP acts_upstream_of_or_within protein metabolic process 14985362 Process
50873 GO:0030163 IMP involved_in protein catabolic process 21376232 Process
50873 GO:0031648 IMP involved_in protein destabilization 19591802 Process
50873 GO:0032436 IMP involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 23858059 Process
50873 GO:0034976 IMP involved_in response to endoplasmic reticulum stress 21113145 Process
50873 GO:0035249 IMP acts_upstream_of_or_within synaptic transmission, glutamatergic 12915482 Process
50873 GO:0042415 IMP acts_upstream_of_or_within norepinephrine metabolic process 15249681 Process
50873 GO:0042417 IMP NOT acts_upstream_of_or_within dopamine metabolic process 15684050 Process
50873 GO:0042417 IMP acts_upstream_of_or_within dopamine metabolic process 12915482 Process
50873 GO:0043524 IMP involved_in negative regulation of neuron apoptotic process 12628165,19591802 Process
50873 GO:0046928 IMP acts_upstream_of_or_within regulation of neurotransmitter secretion 12930822 Process
50873 GO:0050804 IMP acts_upstream_of_or_within modulation of chemical synaptic transmission 12930822 Process
50873 GO:0051583 IMP acts_upstream_of_or_within dopamine uptake involved in synaptic transmission 12915482 Process
50873 GO:0051881 IGI involved_in regulation of mitochondrial membrane potential 24898855 Process
50873 GO:0070585 IMP involved_in protein localization to mitochondrion 23858059 Process
50873 GO:0097237 IDA involved_in cellular response to toxic substance 12628165 Process
50873 GO:0140251 IDA involved_in regulation protein catabolic process at presynapse 29311685 Process
50873 GO:0140251 IEP involved_in regulation protein catabolic process at presynapse 29311685 Process
50873 GO:0140251 IMP involved_in regulation protein catabolic process at presynapse 29311685 Process
50873 GO:0140251 IPI involved_in regulation protein catabolic process at presynapse 29311685 Process
50873 GO:1900242 IDA involved_in regulation of synaptic vesicle endocytosis 29311685 Process
50873 GO:1900242 IEP involved_in regulation of synaptic vesicle endocytosis 29311685 Process
50873 GO:1900242 IMP involved_in regulation of synaptic vesicle endocytosis 29311685 Process
50873 GO:1900242 IPI involved_in regulation of synaptic vesicle endocytosis 29311685 Process
50873 GO:1901215 IMP involved_in negative regulation of neuron death 21376232 Process
50873 GO:1902236 IMP involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 21113145 Process
50873 GO:1902530 IMP involved_in positive regulation of protein linear polyubiquitination 23453807 Process
50873 GO:1903377 IMP involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 23858059 Process
50873 GO:1903382 IGI involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 17116640 Process
50873 GO:1903382 IMP involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 23453807 Process
50873 GO:1903861 IGI involved_in positive regulation of dendrite extension 24898855 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
50873 GO:0005515 IPI enables protein binding 12628165,14532270,16096643,16332688,20064468,21376232,22082830..... Function
50873 GO:0061630 IDA enables ubiquitin protein ligase activity 20064468,28063983 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
50873 GO:0005634 IDA located_in nucleus 24187134 Component
50873 GO:0005737 IDA located_in cytoplasm 24187134 Component
50873 GO:0005739 IDA located_in mitochondrion 23858059,32047033 Component
50873 GO:0032991 IDA part_of protein-containing complex 18190519 Component
50873 GO:0043005 IDA located_in neuron projection 11675120 Component
50873 GO:0098691 IDA is_active_in dopaminergic synapse 29311685 Component
50873 GO:0098691 IEP is_active_in dopaminergic synapse 29311685 Component
50873 GO:0098691 IMP is_active_in dopaminergic synapse 29311685 Component
50873 GO:0098691 IPI is_active_in dopaminergic synapse 29311685 Component