Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5216
  • Symbol: PFN1
  • Description: profilin 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5216 GO:0000774 IDA enables adenyl-nucleotide exchange factor activity 7758455 Function
5216 GO:0001784 IPI enables phosphotyrosine residue binding 24700464 Function
5216 GO:0003723 HDA enables RNA binding 22681889 Function
5216 GO:0003779 IPI enables actin binding 7758455,17914456 Function
5216 GO:0003785 IDA enables actin monomer binding 18573880 Function
5216 GO:0005515 IPI enables protein binding 9822597,9843499,16531231,17470807,18573880,18689676,19000816,1..... Function
5216 GO:0005546 IDA enables phosphatidylinositol-4,5-bisphosphate binding 7758455 Function
5216 GO:0045296 HDA enables cadherin binding 25468996 Function
5216 GO:0070064 IPI enables proline-rich region binding 17914456 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5216 GO:0005634 IDA located_in nucleus 24700464 Component
5216 GO:0005737 IDA located_in cytoplasm 24700464 Component
5216 GO:0005925 HDA located_in focal adhesion 21423176 Component
5216 GO:0005938 IDA located_in cell cortex 24700464 Component
5216 GO:0016020 HDA located_in membrane 19946888 Component
5216 GO:0070062 HDA located_in extracellular exosome 19056867,20458337,23533145 Component
5216 GO:0072562 HDA located_in blood microparticle 22516433 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5216 GO:0010634 IMP involved_in positive regulation of epithelial cell migration 23153535 Process
5216 GO:0030837 IDA involved_in negative regulation of actin filament polymerization 7758455 Process
5216 GO:0030838 IGI involved_in positive regulation of actin filament polymerization 23153535 Process
5216 GO:0032232 IMP involved_in negative regulation of actin filament bundle assembly 23153535 Process
5216 GO:0032781 IDA involved_in positive regulation of ATP-dependent activity 7758455 Process
5216 GO:0050821 IDA involved_in protein stabilization 18573880 Process
5216 GO:0051497 IMP involved_in negative regulation of stress fiber assembly 23153535 Process
5216 GO:1900029 IMP involved_in positive regulation of ruffle assembly 23153535 Process