Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 5291
• Symbol: PIK3CB
• Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
5291	GO:0001952	IMP	acts_upstream_of_or_within	regulation of cell-matrix adhesion	25139353	Process
5291	GO:0003376	IMP	involved_in	sphingosine-1-phosphate receptor signaling pathway	18558630	Process
5291	GO:0010595	IGI	involved_in	positive regulation of endothelial cell migration	18558630	Process
5291	GO:0010628	IMP	acts_upstream_of_or_within	positive regulation of gene expression	25139353	Process
5291	GO:0014065	IGI	involved_in	phosphatidylinositol 3-kinase signaling	30496354	Process
5291	GO:0014065	IMP	involved_in	phosphatidylinositol 3-kinase signaling	18558630,25339672	Process
5291	GO:0016310	IDA	acts_upstream_of_or_within	phosphorylation	25327288	Process
5291	GO:0033031	IMP	involved_in	positive regulation of neutrophil apoptotic process	25339672	Process
5291	GO:0035022	IGI	involved_in	positive regulation of Rac protein signal transduction	18558630	Process
5291	GO:0046854	IDA	involved_in	phosphatidylinositol phosphate biosynthetic process	12502714	Process
5291	GO:0051000	IMP	acts_upstream_of	positive regulation of nitric-oxide synthase activity	18558630	Process
5291	GO:0051897	IMP	involved_in	positive regulation of protein kinase B signaling	18558630	Process
5291	GO:0051898	IGI	involved_in	negative regulation of protein kinase B signaling	30496354	Process
5291	GO:1900747	IGI	involved_in	negative regulation of vascular endothelial growth factor signaling pathway	30496354	Process
5291	GO:1903671	IMP	involved_in	negative regulation of sprouting angiogenesis	30496354	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
5291	GO:0005515	IPI	enables	protein binding	19380743,20713702,22402981,25241761,25556234,25814554,26496610.....	Function
5291	GO:0016301	IDA	enables	kinase activity	25327288	Function
5291	GO:0046934	IDA	enables	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	12502714	Function
5291	GO:0106310	IDA	enables	protein serine kinase activity	12502714	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
5291	GO:0005634	IDA	located_in	nucleus	30496354	Component
5291	GO:0005654	IDA	located_in	nucleoplasm		Component
5291	GO:0005730	IDA	located_in	nucleolus		Component
5291	GO:0005943	IPI	part_of	phosphatidylinositol 3-kinase complex, class IA	20713702,22402981	Component
5291	GO:0030496	IDA	located_in	midbody		Component
5291	GO:0043231	IDA	located_in	intracellular membrane-bounded organelle		Component