Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5311
  • Symbol: PKD2
  • Description: polycystin 2, transient receptor potential cation channel

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5311 GO:0001658 IEP involved_in branching involved in ureteric bud morphogenesis 11891195 Process
5311 GO:0001889 IEP involved_in liver development 11891195 Process
5311 GO:0001947 IMP involved_in heart looping 21719175 Process
5311 GO:0006816 IDA involved_in calcium ion transport 11252306,27214281 Process
5311 GO:0007507 IEP involved_in heart development 11891195 Process
5311 GO:0021510 IEP involved_in spinal cord development 11891195 Process
5311 GO:0021915 IEP involved_in neural tube development 11891195 Process
5311 GO:0031587 IMP involved_in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 16223735 Process
5311 GO:0035502 IEP involved_in metanephric part of ureteric bud development 11891195 Process
5311 GO:0035725 IDA involved_in sodium ion transmembrane transport 11252306 Process
5311 GO:0035725 IMP involved_in sodium ion transmembrane transport 27071085 Process
5311 GO:0035904 IEP involved_in aorta development 11891195 Process
5311 GO:0042127 IMP involved_in regulation of cell population proliferation 15001556 Process
5311 GO:0042994 IMP involved_in cytoplasmic sequestering of transcription factor 16311606 Process
5311 GO:0044782 IMP acts_upstream_of_or_within cilium organization 28154160 Process
5311 GO:0045429 IMP involved_in positive regulation of nitric oxide biosynthetic process 19265036 Process
5311 GO:0045737 IMP involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity 16311606 Process
5311 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 16311606 Process
5311 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 9192675 Process
5311 GO:0051209 IDA involved_in release of sequestered calcium ion into cytosol 11854751 Process
5311 GO:0051209 IMP involved_in release of sequestered calcium ion into cytosol 19265036 Process
5311 GO:0051262 IDA involved_in protein tetramerization 29899465 Process
5311 GO:0051289 IDA involved_in protein homotetramerization 28092368 Process
5311 GO:0051290 IDA involved_in protein heterotetramerization 30093605 Process
5311 GO:0061441 IEP involved_in renal artery morphogenesis 11891195 Process
5311 GO:0070588 IDA involved_in calcium ion transmembrane transport 11854751 Process
5311 GO:0071320 IMP involved_in cellular response to cAMP 26269590 Process
5311 GO:0071464 IDA involved_in cellular response to hydrostatic pressure 16025301 Process
5311 GO:0071470 IDA involved_in cellular response to osmotic stress 16025301 Process
5311 GO:0071498 IMP involved_in cellular response to fluid shear stress 19265036 Process
5311 GO:0071805 IDA involved_in potassium ion transmembrane transport 26269590 Process
5311 GO:0071805 IMP involved_in potassium ion transmembrane transport 27071085 Process
5311 GO:0071910 IMP involved_in determination of liver left/right asymmetry 21719175 Process
5311 GO:0072075 IEP involved_in metanephric mesenchyme development 11891195 Process
5311 GO:0072164 IEP involved_in mesonephric tubule development 11891195 Process
5311 GO:0072177 IEP involved_in mesonephric duct development 11891195 Process
5311 GO:0072208 IEP involved_in metanephric smooth muscle tissue development 11891195 Process
5311 GO:0072214 IEP involved_in metanephric cortex development 11891195 Process
5311 GO:0072218 IEP involved_in metanephric ascending thin limb development 11891195 Process
5311 GO:0072219 IEP involved_in metanephric cortical collecting duct development 11891195 Process
5311 GO:0072235 IEP involved_in metanephric distal tubule development 11891195 Process
5311 GO:0072284 IEP involved_in metanephric S-shaped body morphogenesis 11891195 Process
5311 GO:0090279 IDA involved_in regulation of calcium ion import 11854751 Process
5311 GO:0098662 IMP involved_in inorganic cation transmembrane transport 29899465 Process
5311 GO:0198738 IDA involved_in cell-cell signaling by wnt 27214281 Process
5311 GO:2000134 IMP involved_in negative regulation of G1/S transition of mitotic cell cycle 16311606 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5311 GO:0002133 IPI part_of polycystin complex 11901144 Component
5311 GO:0005737 IDA located_in cytoplasm 10770959 Component
5311 GO:0005737 IMP located_in cytoplasm 16311606 Component
5311 GO:0005783 IDA located_in endoplasmic reticulum 10760273,15123714,15692563,19801576,28154160 Component
5311 GO:0005783 IMP located_in endoplasmic reticulum 16223735 Component
5311 GO:0005789 IDA located_in endoplasmic reticulum membrane 11854751,15001556 Component
5311 GO:0005829 IDA located_in cytosol Component
5311 GO:0005886 IDA located_in plasma membrane 15692563,16025301,21044049,26269590,28092368,29899465,30093605..... Component
5311 GO:0005886 IMP located_in plasma membrane 27071085 Component
5311 GO:0005929 IDA located_in cilium 28154160 Component
5311 GO:0009925 IDA located_in basal plasma membrane 10770959 Component
5311 GO:0030027 IDA located_in lamellipodium 10760273 Component
5311 GO:0034703 IDA part_of cation channel complex 30093605 Component
5311 GO:0036064 IDA located_in ciliary basal body 15337773 Component
5311 GO:0045180 IDA located_in basal cortex 10770959 Component
5311 GO:0070062 HDA located_in extracellular exosome 19056867 Component
5311 GO:0072686 IDA located_in mitotic spindle 15123714 Component
5311 GO:0098553 IDA located_in lumenal side of endoplasmic reticulum membrane 21044049 Component
5311 GO:0098554 IDA located_in cytoplasmic side of endoplasmic reticulum membrane 21044049 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5311 GO:0005102 IPI enables signaling receptor binding 16223735 Function
5311 GO:0005244 IDA enables voltage-gated monoatomic ion channel activity 11854751 Function
5311 GO:0005245 IDA enables voltage-gated calcium channel activity 11252306,15692563 Function
5311 GO:0005248 IDA enables voltage-gated sodium channel activity 11252306 Function
5311 GO:0005248 IMP enables voltage-gated sodium channel activity 27071085 Function
5311 GO:0005249 IMP enables voltage-gated potassium channel activity 27071085 Function
5311 GO:0005261 IMP enables monoatomic cation channel activity 29899465 Function
5311 GO:0005262 IDA contributes_to calcium channel activity 27214281 Function
5311 GO:0005267 IDA enables potassium channel activity 26269590 Function
5311 GO:0005509 IDA enables calcium ion binding 24990821 Function
5311 GO:0005515 IPI enables protein binding 9171830,9192675,10097141,10760273,12525172,12809519,15123714,1..... Function
5311 GO:0008092 IDA enables cytoskeletal protein binding 10760273 Function
5311 GO:0022843 IDA enables voltage-gated monoatomic cation channel activity 11252306 Function
5311 GO:0042802 IPI enables identical protein binding 20168298,27768895,28092368 Function
5311 GO:0042803 IDA enables protein homodimerization activity 9192675 Function
5311 GO:0042805 IDA enables actinin binding 15843396 Function
5311 GO:0043398 IPI enables HLH domain binding 16311606 Function
5311 GO:0044325 IPI enables transmembrane transporter binding 10097141 Function
5311 GO:0048763 IDA enables calcium-induced calcium release activity 11854751 Function
5311 GO:0051219 IPI enables phosphoprotein binding 19801576 Function