Gene Ontology

Gene Info

• Species: Rat (Rattus norvegicus)
• GeneID: 54226
• Symbol: App
• Description: amyloid beta precursor protein

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
54226	GO:0001878	IDA	involved_in	response to yeast	20209079	Process
54226	GO:0010288	IEP	involved_in	response to lead ion	16230335,29908845	Process
54226	GO:0010469	IDA	involved_in	regulation of signaling receptor activity	15447668	Process
54226	GO:0019731	IDA	involved_in	antibacterial humoral response	20209079	Process
54226	GO:0019732	IDA	involved_in	antifungal humoral response	20209079	Process
54226	GO:0043406	IDA	involved_in	positive regulation of MAP kinase activity	11404397	Process
54226	GO:0043406	IGI	involved_in	positive regulation of MAP kinase activity	11404397	Process
54226	GO:0043408	IDA	involved_in	regulation of MAPK cascade	15447668	Process
54226	GO:0045087	IDA	involved_in	innate immune response	20209079	Process
54226	GO:0050829	IDA	involved_in	defense response to Gram-negative bacterium	20209079	Process
54226	GO:0050830	IDA	involved_in	defense response to Gram-positive bacterium	20209079	Process
54226	GO:0051247	IDA	involved_in	positive regulation of protein metabolic process	11404397	Process
54226	GO:0061097	IDA	involved_in	regulation of protein tyrosine kinase activity	15447668	Process
54226	GO:0061844	IDA	involved_in	antimicrobial humoral immune response mediated by antimicrobial peptide	20209079	Process
54226	GO:0070374	IDA	involved_in	positive regulation of ERK1 and ERK2 cascade	11404397	Process
54226	GO:0070374	IGI	involved_in	positive regulation of ERK1 and ERK2 cascade	11404397	Process
54226	GO:0070555	IDA	involved_in	response to interleukin-1	20395292	Process
54226	GO:0071280	IEP	involved_in	cellular response to copper ion	18583042	Process
54226	GO:0071287	IEP	involved_in	cellular response to manganese ion	18583042	Process
54226	GO:0071320	IEP	involved_in	cellular response to cAMP	9144253	Process
54226	GO:0071874	IMP	involved_in	cellular response to norepinephrine stimulus	9144253	Process
54226	GO:1902951	IDA	involved_in	negative regulation of dendritic spine maintenance	18568035	Process
54226	GO:1905945	IGI	involved_in	regulation of response to calcium ion	11404397	Process
54226	GO:1990090	IEP	involved_in	cellular response to nerve growth factor stimulus	10821917	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
54226	GO:0005515	IPI	enables	protein binding	9461550,16118793	Function
54226	GO:0016504	IDA	enables	peptidase activator activity	12493564	Function
54226	GO:0043167	EXP	enables	ion binding	22225807	Function
54226	GO:0070851	IPI	enables	growth factor receptor binding	19334058	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
54226	GO:0005615	IDA	located_in	extracellular space	14615045	Component
54226	GO:0008021	IDA	NOT located_in	synaptic vesicle	8987743	Component
54226	GO:0009986	IDA	located_in	cell surface	8987743,29914798	Component
54226	GO:0030424	IDA	located_in	axon	8987743	Component
54226	GO:0030426	IDA	located_in	growth cone	12843239	Component
54226	GO:0043195	HDA	located_in	terminal bouton	24876496	Component
54226	GO:0044304	IDA	located_in	main axon	12843239	Component
54226	GO:0097449	IDA	located_in	astrocyte projection	8097074	Component
54226	GO:0098992	IDA	is_active_in	neuronal dense core vesicle	29577889	Component
54226	GO:1990761	IDA	located_in	growth cone lamellipodium	12843239	Component
54226	GO:1990812	IDA	located_in	growth cone filopodium	12843239	Component