Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5538
  • Symbol: PPT1
  • Description: palmitoyl-protein thioesterase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5538 GO:0002084 IDA involved_in protein depalmitoylation 10658183,10737604 Process
5538 GO:0006898 IMP acts_upstream_of_or_within receptor-mediated endocytosis 16542649 Process
5538 GO:0006907 IMP acts_upstream_of_or_within pinocytosis 16542649 Process
5538 GO:0007042 IMP involved_in lysosomal lumen acidification 11722572 Process
5538 GO:0007399 IMP involved_in nervous system development 7637805 Process
5538 GO:0007420 IMP involved_in brain development 7637805 Process
5538 GO:0015031 IMP involved_in protein transport 10737604 Process
5538 GO:0016042 IDA involved_in lipid catabolic process 8816748 Process
5538 GO:0030308 IMP involved_in negative regulation of cell growth 10737604 Process
5538 GO:0031579 IMP involved_in membrane raft organization 15929065 Process
5538 GO:0043066 IDA involved_in negative regulation of apoptotic process 15929065 Process
5538 GO:0043524 IMP involved_in negative regulation of neuron apoptotic process 10737604,11020216 Process
5538 GO:0048260 IMP involved_in positive regulation of receptor-mediated endocytosis 16542649 Process
5538 GO:0048549 IMP involved_in positive regulation of pinocytosis 16542649 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5538 GO:0005515 IPI enables protein binding 17237713,19941651,25544563,32814053 Function
5538 GO:0008474 IDA enables palmitoyl-(protein) hydrolase activity 10658183,10737604 Function
5538 GO:0008474 IMP enables palmitoyl-(protein) hydrolase activity 7637805 Function
5538 GO:0016290 IDA enables palmitoyl-CoA hydrolase activity 10658183 Function
5538 GO:0035727 IDA enables lysophosphatidic acid binding 18317235 Function
5538 GO:0120146 IDA enables sulfatide binding 18317235 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5538 GO:0005576 IDA located_in extracellular region 8895569 Component
5538 GO:0005634 IDA located_in nucleus 10992246 Component
5538 GO:0005764 IDA located_in lysosome 8895569,11020216,19941651 Component
5538 GO:0005794 IDA located_in Golgi apparatus 7637805 Component
5538 GO:0008021 IDA located_in synaptic vesicle 12483688 Component
5538 GO:0016020 HDA located_in membrane 19946888 Component
5538 GO:0030424 IDA located_in axon 12483688 Component
5538 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
5538 GO:0045121 IDA located_in membrane raft 15929065 Component
5538 GO:0070062 HDA located_in extracellular exosome 23533145 Component