Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5621
  • Symbol: PRNP
  • Description: prion protein (Kanno blood group)

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5621 GO:0001540 IDA enables amyloid-beta binding 24012003 Function
5621 GO:0001540 IPI enables amyloid-beta binding 22820466 Function
5621 GO:0005507 IDA enables copper ion binding 11900542 Function
5621 GO:0005515 IPI enables protein binding 16286452,17500595,18482256,21920025,22285492,22484317,23236467..... Function
5621 GO:0008017 IDA enables microtubule binding 16004966 Function
5621 GO:0015631 IDA enables tubulin binding 16004966 Function
5621 GO:0031802 IPI enables type 5 metabotropic glutamate receptor binding 24012003 Function
5621 GO:0031805 IDA NOT enables type 8 metabotropic glutamate receptor binding 24012003 Function
5621 GO:0042802 IPI enables identical protein binding 16286452,18025469,18436646,19204296,19278656,19927125,20564047..... Function
5621 GO:0044877 IPI enables protein-containing complex binding 23386614 Function
5621 GO:0060090 IDA enables molecular adaptor activity 30401430 Function
5621 GO:0140693 IDA enables molecular condensate scaffold activity 30401430 Function
5621 GO:1903136 IMP enables cuprous ion binding 20564047 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5621 GO:0005829 IDA located_in cytosol Component
5621 GO:0005886 IDA located_in plasma membrane 16254249,18419754 Component
5621 GO:0009986 HDA located_in cell surface 19581412 Component
5621 GO:0009986 IDA located_in cell surface 18419754 Component
5621 GO:0016234 IMP located_in inclusion body 20564047 Component
5621 GO:0030425 IDA colocalizes_with dendrite 24012003 Component
5621 GO:0031965 IDA located_in nuclear membrane Component
5621 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
5621 GO:0045121 IDA located_in membrane raft 16254249 Component
5621 GO:0045121 IMP located_in membrane raft 23386614 Component
5621 GO:0070062 HDA located_in extracellular exosome 19056867 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5621 GO:0031648 IMP involved_in protein destabilization 20564047 Process
5621 GO:0035584 IGI involved_in calcium-mediated signaling using intracellular calcium source 24012003 Process
5621 GO:0043525 IMP involved_in positive regulation of neuron apoptotic process 20564047 Process
5621 GO:0050731 IDA involved_in positive regulation of peptidyl-tyrosine phosphorylation 22820466 Process
5621 GO:0061098 IGI involved_in positive regulation of protein tyrosine kinase activity 24012003 Process
5621 GO:0071280 IDA acts_upstream_of_or_within cellular response to copper ion 16254249 Process
5621 GO:1902938 IGI involved_in regulation of intracellular calcium activated chloride channel activity 24012003 Process
5621 GO:1904646 IGI involved_in cellular response to amyloid-beta 24012003 Process