Gene Ontology

Gene Info

  • Species: Rat (Rattus norvegicus)
  • GeneID: 56816
  • Symbol: Prkn
  • Description: parkin RBR E3 ubiquitin protein ligase

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
56816 GO:0000139 IDA located_in Golgi membrane 12150907,12472897 Component
56816 GO:0005737 IDA located_in cytoplasm 12150907 Component
56816 GO:0005739 IDA colocalizes_with mitochondrion 20457763 Component
56816 GO:0005789 IDA located_in endoplasmic reticulum membrane 12150907 Component
56816 GO:0005829 IDA located_in cytosol 20457763 Component
56816 GO:0008021 IDA located_in synaptic vesicle 15480834 Component
56816 GO:0030424 IDA located_in axon 28761318 Component
56816 GO:0030672 IDA is_active_in synaptic vesicle membrane 15480834 Component
56816 GO:0030672 IDA located_in synaptic vesicle membrane 11432972 Component
56816 GO:0043005 IDA located_in neuron projection 12925569 Component
56816 GO:0043025 IDA located_in neuronal cell body 12472897,28761318 Component
56816 GO:0043195 IDA located_in terminal bouton 12925569 Component
56816 GO:0045202 IDA located_in synapse 12150907 Component
56816 GO:0048471 IDA located_in perinuclear region of cytoplasm 12925569 Component
56816 GO:0097708 IDA located_in intracellular vesicle 12472897 Component
56816 GO:0098793 IDA is_active_in presynapse 15480834 Component
56816 GO:0098793 IDA located_in presynapse 12000718 Component
56816 GO:0098794 IDA is_active_in postsynapse 15480834 Component
56816 GO:0098978 IDA is_active_in glutamatergic synapse 25316086 Component
56816 GO:0098978 IMP is_active_in glutamatergic synapse 25316086 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
56816 GO:0000422 IDA involved_in autophagy of mitochondrion 20457763 Process
56816 GO:0006986 IEP involved_in response to unfolded protein 12472897 Process
56816 GO:0009410 IEP involved_in response to xenobiotic stimulus 12618056 Process
56816 GO:0010918 IMP involved_in positive regulation of mitochondrial membrane potential 24096089 Process
56816 GO:0014850 IEP involved_in response to muscle activity 26678157 Process
56816 GO:0016567 IDA involved_in protein ubiquitination 20457763 Process
56816 GO:0034976 IEP involved_in response to endoplasmic reticulum stress 12415119 Process
56816 GO:0035774 IMP involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus 24096089 Process
56816 GO:0043065 IMP involved_in positive regulation of apoptotic process 28673964 Process
56816 GO:0043524 IGI acts_upstream_of_or_within negative regulation of neuron apoptotic process 20823226 Process
56816 GO:0043524 IMP involved_in negative regulation of neuron apoptotic process 28761318 Process
56816 GO:0043653 IMP involved_in mitochondrial fragmentation involved in apoptotic process 28761318 Process
56816 GO:0051412 IEP involved_in response to corticosterone 14663185 Process
56816 GO:0051646 IDA involved_in mitochondrion localization 20457763 Process
56816 GO:0051967 IMP involved_in negative regulation of synaptic transmission, glutamatergic 19033459 Process
56816 GO:0070585 IDA involved_in protein localization to mitochondrion 20457763 Process
56816 GO:0071287 IEP involved_in cellular response to manganese ion 19781568 Process
56816 GO:0090258 IMP involved_in negative regulation of mitochondrial fission 24096089 Process
56816 GO:0090394 IMP involved_in negative regulation of excitatory postsynaptic potential 19033459 Process
56816 GO:0099072 IDA involved_in regulation of postsynaptic membrane neurotransmitter receptor levels 25316086 Process
56816 GO:0099072 IEP involved_in regulation of postsynaptic membrane neurotransmitter receptor levels 25316086 Process
56816 GO:0099072 IMP involved_in regulation of postsynaptic membrane neurotransmitter receptor levels 25316086 Process
56816 GO:1901526 IMP involved_in positive regulation of mitophagy 28608965 Process
56816 GO:1903377 IGI involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 23392669 Process
56816 GO:1903427 IMP involved_in negative regulation of reactive oxygen species biosynthetic process 24096089 Process
56816 GO:1904643 IEP involved_in response to curcumin 28698153 Process
56816 GO:1904845 IEP involved_in cellular response to L-glutamine 28761318 Process
56816 GO:1904881 IDA involved_in cellular response to hydrogen sulfide 28608965 Process
56816 GO:1905232 IDA involved_in cellular response to L-glutamate 25478815 Process
56816 GO:2001171 IMP involved_in positive regulation of ATP biosynthetic process 24096089 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
56816 GO:0005515 IPI enables protein binding 16332688,24879156 Function
56816 GO:0019901 IPI enables protein kinase binding 28608965 Function
56816 GO:0044877 IDA enables protein-containing complex binding 12716939 Function