Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5728
  • Symbol: PTEN
  • Description: phosphatase and tensin homolog

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5728 GO:0001933 IDA involved_in negative regulation of protein phosphorylation 20123964 Process
5728 GO:0006470 IDA involved_in protein dephosphorylation 9256433 Process
5728 GO:0007056 IDA involved_in spindle assembly involved in female meiosis 31492966 Process
5728 GO:0008285 IDA involved_in negative regulation of cell population proliferation 19057511 Process
5728 GO:0008285 IMP involved_in negative regulation of cell population proliferation 10468583,17880912 Process
5728 GO:0010719 IMP involved_in negative regulation of epithelial to mesenchymal transition 27919618 Process
5728 GO:0014065 IDA involved_in phosphatidylinositol 3-kinase signaling 9593664 Process
5728 GO:0014067 IDA involved_in negative regulation of phosphatidylinositol 3-kinase signaling 31492966 Process
5728 GO:0030336 IMP involved_in negative regulation of cell migration 9616126,17880912,21573166 Process
5728 GO:0031647 IMP involved_in regulation of protein stability 10866658 Process
5728 GO:0033137 IMP involved_in negative regulation of peptidyl-serine phosphorylation 10918569 Process
5728 GO:0045736 IDA involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity 21241890 Process
5728 GO:0046856 IDA involved_in phosphatidylinositol dephosphorylation 9593664,9811831 Process
5728 GO:0046856 IMP involved_in phosphatidylinositol dephosphorylation 21828076 Process
5728 GO:0050821 IDA involved_in protein stabilization 20123964 Process
5728 GO:0051091 IMP involved_in positive regulation of DNA-binding transcription factor activity 20123964 Process
5728 GO:0051548 IMP involved_in negative regulation of keratinocyte migration 27919618 Process
5728 GO:0051895 IMP involved_in negative regulation of focal adhesion assembly 9616126 Process
5728 GO:0051898 IMP acts_upstream_of_or_within negative regulation of protein kinase B signaling 26280536 Process
5728 GO:0051898 IMP involved_in negative regulation of protein kinase B signaling 10760291,21573166,22879939 Process
5728 GO:0060070 IDA involved_in canonical Wnt signaling pathway 20123964 Process
5728 GO:0070373 IMP involved_in negative regulation of ERK1 and ERK2 cascade Process
5728 GO:0071257 IMP involved_in cellular response to electrical stimulus 27919618 Process
5728 GO:1902807 IDA involved_in negative regulation of cell cycle G1/S phase transition 10918569 Process
5728 GO:1903690 IMP involved_in negative regulation of wound healing, spreading of epidermal cells 27919618 Process
5728 GO:1903984 IMP involved_in positive regulation of TRAIL-activated apoptotic signaling pathway Process
5728 GO:1904668 IDA involved_in positive regulation of ubiquitin protein ligase activity 21241890 Process
5728 GO:1904706 IMP involved_in negative regulation of vascular associated smooth muscle cell proliferation 26208095 Process
5728 GO:2000060 IDA involved_in positive regulation of ubiquitin-dependent protein catabolic process 21241890 Process
5728 GO:2000134 IDA involved_in negative regulation of G1/S transition of mitotic cell cycle 21241890 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5728 GO:0004438 IDA enables phosphatidylinositol-3-phosphate phosphatase activity 9811831 Function
5728 GO:0004721 IDA enables phosphoprotein phosphatase activity 21241890 Function
5728 GO:0004722 IDA enables protein serine/threonine phosphatase activity 9256433 Function
5728 GO:0004725 IDA enables protein tyrosine phosphatase activity 9256433 Function
5728 GO:0005515 IPI enables protein binding 15355975,15951562,16456542,17242191,17274640,19345329,19369943..... Function
5728 GO:0010997 IPI enables anaphase-promoting complex binding 21241890 Function
5728 GO:0016314 IDA enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 9593664,9811831 Function
5728 GO:0019899 IPI enables enzyme binding 16845383 Function
5728 GO:0030165 IPI enables PDZ domain binding 10646847,10760291 Function
5728 GO:0042802 IPI enables identical protein binding 24766807 Function
5728 GO:0051717 IDA enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity 9593664 Function
5728 GO:0051800 IDA enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity 9811831 Function
5728 GO:0052866 IDA enables phosphatidylinositol phosphate phosphatase activity 9811831 Function
5728 GO:1990381 IPI enables ubiquitin-specific protease binding 26280536 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5728 GO:0005634 IDA located_in nucleus 17218261,21241890,24862762 Component
5728 GO:0005654 IDA located_in nucleoplasm Component
5728 GO:0005737 IDA located_in cytoplasm 9187108,10760291,10940933,21241890,24862762 Component
5728 GO:0005829 IDA located_in cytosol Component
5728 GO:0005886 IDA located_in plasma membrane 10760291 Component
5728 GO:0009898 IDA located_in cytoplasmic side of plasma membrane 10940933 Component
5728 GO:0016324 IMP located_in apical plasma membrane 24862762 Component
5728 GO:0042995 IDA located_in cell projection 10760291,25007873 Component