Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5770
  • Symbol: PTPN1
  • Description: protein tyrosine phosphatase non-receptor type 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5770 GO:0003723 HDA enables RNA binding 22658674 Function
5770 GO:0004725 IDA enables protein tyrosine phosphatase activity 18074158,21707536,22169477 Function
5770 GO:0005515 IPI enables protein binding 8702689,8940134,8999839,9050838,9355745,9407132,9418872,956691..... Function
5770 GO:0008270 IDA enables zinc ion binding 18074158 Function
5770 GO:0019899 IPI enables enzyme binding 22169477 Function
5770 GO:0019901 IPI enables protein kinase binding 22169477 Function
5770 GO:0030971 IPI enables receptor tyrosine kinase binding 18819921 Function
5770 GO:0045296 HDA enables cadherin binding 25468996 Function
5770 GO:0046875 IPI enables ephrin receptor binding 21135139 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5770 GO:0005769 IDA located_in early endosome 21135139 Component
5770 GO:0005783 IDA located_in endoplasmic reticulum Component
5770 GO:0005886 IDA colocalizes_with plasma membrane 21135139 Component
5770 GO:0032991 IDA part_of protein-containing complex 28246125 Component
5770 GO:0098554 IDA located_in cytoplasmic side of endoplasmic reticulum membrane 1739967 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5770 GO:0006470 IMP involved_in protein dephosphorylation 22045810 Process
5770 GO:0009966 IMP involved_in regulation of signal transduction 21135139 Process
5770 GO:0030036 IMP involved_in actin cytoskeleton organization 21135139 Process
5770 GO:0030100 IDA involved_in regulation of endocytosis 21135139 Process
5770 GO:0030968 IDA involved_in endoplasmic reticulum unfolded protein response 22169477 Process
5770 GO:0033157 IMP involved_in regulation of intracellular protein transport 22045810 Process
5770 GO:0035335 IDA involved_in peptidyl-tyrosine dephosphorylation 21135139 Process
5770 GO:0035335 IMP involved_in peptidyl-tyrosine dephosphorylation 14966296 Process
5770 GO:0035791 IMP involved_in platelet-derived growth factor receptor-beta signaling pathway 14966296 Process
5770 GO:0043407 IMP involved_in negative regulation of MAP kinase activity 22045810 Process
5770 GO:0061098 IDA involved_in positive regulation of protein tyrosine kinase activity 21216966 Process
5770 GO:1902202 IMP involved_in regulation of hepatocyte growth factor receptor signaling pathway 18819921 Process
5770 GO:1903898 IDA involved_in negative regulation of PERK-mediated unfolded protein response 21216966 Process
5770 GO:2000646 IMP involved_in positive regulation of receptor catabolic process 22045810 Process