Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5781
  • Symbol: PTPN11
  • Description: protein tyrosine phosphatase non-receptor type 11

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5781 GO:0001784 IMP enables phosphotyrosine residue binding 12051764 Function
5781 GO:0001784 IPI enables phosphotyrosine residue binding 11986327,12051764 Function
5781 GO:0004721 IDA enables phosphoprotein phosphatase activity 15133037 Function
5781 GO:0004725 EXP enables protein tyrosine phosphatase activity 22759635,26617336 Function
5781 GO:0004725 IDA enables protein tyrosine phosphatase activity 15133037,23029125,26742426,28074573 Function
5781 GO:0004725 IMP enables protein tyrosine phosphatase activity 10206955,17562706 Function
5781 GO:0004726 IDA enables non-membrane spanning protein tyrosine phosphatase activity 16481357 Function
5781 GO:0004726 IMP enables non-membrane spanning protein tyrosine phosphatase activity 10655584 Function
5781 GO:0005158 IPI enables insulin receptor binding 7493946 Function
5781 GO:0005515 IPI enables protein binding 7493946,7504175,7513703,7523381,7530043,7642582,7688466,811989..... Function
5781 GO:0030159 IPI enables signaling receptor complex adaptor activity 7493946 Function
5781 GO:0045296 IPI enables cadherin binding 15985432 Function
5781 GO:0050839 IPI enables cell adhesion molecule binding 15985432 Function
5781 GO:0060090 IDA enables molecular adaptor activity 26358190 Function
5781 GO:1990782 IPI enables protein tyrosine kinase binding 15985432 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5781 GO:0005634 IDA located_in nucleus 15133037,26742426 Component
5781 GO:0005737 IDA located_in cytoplasm 10940933,15133037,26742426 Component
5781 GO:0032991 IMP part_of protein-containing complex 17562706 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5781 GO:0006470 IMP involved_in protein dephosphorylation 19275884 Process
5781 GO:0007420 IMP involved_in brain development 11704759 Process
5781 GO:0007507 IMP involved_in heart development 12058348 Process
5781 GO:0008543 IMP involved_in fibroblast growth factor receptor signaling pathway 16481357 Process
5781 GO:0032480 IDA involved_in negative regulation of type I interferon production 26358190 Process
5781 GO:0033628 IMP involved_in regulation of cell adhesion mediated by integrin 10655584 Process
5781 GO:0035335 IDA involved_in peptidyl-tyrosine dephosphorylation 15133037 Process
5781 GO:0035335 IMP involved_in peptidyl-tyrosine dephosphorylation 10655584,17562706 Process
5781 GO:0036302 IMP involved_in atrioventricular canal development 12058348 Process
5781 GO:0038127 IDA involved_in ERBB signaling pathway 15133037 Process
5781 GO:0043254 IDA involved_in regulation of protein-containing complex assembly 7493946 Process
5781 GO:0046326 IDA involved_in positive regulation of glucose import 7493946 Process
5781 GO:0046628 IDA involved_in positive regulation of insulin receptor signaling pathway 7493946 Process
5781 GO:0048013 IDA involved_in ephrin receptor signaling pathway 10655584 Process
5781 GO:0048806 IMP involved_in genitalia development 12058348 Process
5781 GO:0048839 IMP involved_in inner ear development 12058348 Process
5781 GO:0050731 IMP involved_in positive regulation of peptidyl-tyrosine phosphorylation 26706435 Process
5781 GO:0060325 IMP involved_in face morphogenesis 11704759 Process
5781 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 28074573 Process
5781 GO:0071364 IMP involved_in cellular response to epidermal growth factor stimulus 28074573 Process