Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5879
  • Symbol: RAC1
  • Description: Rac family small GTPase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5879 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 23633677 Process
5879 GO:0003376 IMP involved_in sphingosine-1-phosphate receptor signaling pathway 18558630 Process
5879 GO:0007264 IMP involved_in small GTPase mediated signal transduction 26934001 Process
5879 GO:0008361 IGI involved_in regulation of cell size 22467863 Process
5879 GO:0008361 IMP involved_in regulation of cell size 22467863 Process
5879 GO:0010591 IGI involved_in regulation of lamellipodium assembly 8625410 Process
5879 GO:0010592 IDA acts_upstream_of_or_within positive regulation of lamellipodium assembly 15467718 Process
5879 GO:0010592 IMP involved_in positive regulation of lamellipodium assembly 8625410,19625648 Process
5879 GO:0010595 IMP involved_in positive regulation of endothelial cell migration 18558630 Process
5879 GO:0010764 IDA involved_in negative regulation of fibroblast migration 19126672 Process
5879 GO:0010811 IGI involved_in positive regulation of cell-substrate adhesion 20926685 Process
5879 GO:0016477 IDA involved_in cell migration 23512198 Process
5879 GO:0016477 IMP involved_in cell migration 26934001 Process
5879 GO:0030032 IMP involved_in lamellipodium assembly 9312003 Process
5879 GO:0030036 IGI acts_upstream_of_or_within actin cytoskeleton organization 19890013 Process
5879 GO:0030334 IMP involved_in regulation of cell migration 19934221,22036506 Process
5879 GO:0031116 IMP involved_in positive regulation of microtubule polymerization 25198505 Process
5879 GO:0031529 IDA acts_upstream_of_or_within ruffle organization 15467718 Process
5879 GO:0032707 IDA involved_in negative regulation of interleukin-23 production 16982892 Process
5879 GO:0034446 IMP involved_in substrate adhesion-dependent cell spreading 19625648,28886345 Process
5879 GO:0048012 IMP involved_in hepatocyte growth factor receptor signaling pathway 25198505 Process
5879 GO:0048870 IDA involved_in cell motility 19403692 Process
5879 GO:0051179 IDA involved_in localization 12874273 Process
5879 GO:0051492 IGI involved_in regulation of stress fiber assembly 8625410 Process
5879 GO:0051496 IDA involved_in positive regulation of stress fiber assembly 23129259 Process
5879 GO:0051496 IMP involved_in positive regulation of stress fiber assembly 8625410 Process
5879 GO:0051668 IMP involved_in localization within membrane 16636067 Process
5879 GO:0051894 IDA involved_in positive regulation of focal adhesion assembly 23129259 Process
5879 GO:0060263 IDA involved_in regulation of respiratory burst 16636067 Process
5879 GO:0090023 IMP involved_in positive regulation of neutrophil chemotaxis 19625648 Process
5879 GO:0097178 IMP involved_in ruffle assembly 10036235 Process
5879 GO:1900026 IDA involved_in positive regulation of substrate adhesion-dependent cell spreading 23129259 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5879 GO:0003924 IDA enables GTPase activity 19787194,27917469 Function
5879 GO:0005515 IPI enables protein binding 7673236,8625410,8670882,9312003,9739079,10051605,11030651,1126..... Function
5879 GO:0005525 IDA enables GTP binding 12551911,15467718,15601624,22036506,23620790 Function
5879 GO:0005525 IMP enables GTP binding 19625648 Function
5879 GO:0019899 IPI enables enzyme binding 16636067 Function
5879 GO:0019901 IPI enables protein kinase binding 8625410 Function
5879 GO:0031996 IPI enables thioesterase binding 12612085 Function
5879 GO:0044877 IDA enables protein-containing complex binding 21107423 Function
5879 GO:0060090 IPI enables molecular adaptor activity 12874273 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5879 GO:0005634 IDA located_in nucleus 12551911 Component
5879 GO:0005737 IDA located_in cytoplasm 19625648 Component
5879 GO:0005802 IDA located_in trans-Golgi network 12915445 Component
5879 GO:0005884 IDA colocalizes_with actin filament 19625648 Component
5879 GO:0005886 IDA located_in plasma membrane 10036235 Component
5879 GO:0005925 HDA located_in focal adhesion 21423176 Component
5879 GO:0005938 IDA located_in cell cortex 19126672 Component
5879 GO:0030027 IDA located_in lamellipodium 19126672,19625648 Component
5879 GO:0032587 IDA located_in ruffle membrane 20875796 Component
5879 GO:0036464 IDA located_in cytoplasmic ribonucleoprotein granule 15121898 Component
5879 GO:0043197 IDA located_in dendritic spine 24352656 Component
5879 GO:0055038 IDA located_in recycling endosome membrane 10036235 Component
5879 GO:0070062 HDA located_in extracellular exosome 20458337,23533145 Component
5879 GO:0098794 IDA is_active_in postsynapse 15800193,24352656 Component
5879 GO:0098794 IMP is_active_in postsynapse 15800193,24352656 Component
5879 GO:0098978 IDA is_active_in glutamatergic synapse 15800193,24352656 Component
5879 GO:0098978 IMP is_active_in glutamatergic synapse 15800193,24352656 Component