Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 59287
  • Symbol: Ncstn
  • Description: nicastrin

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
59287 GO:0002262 IMP acts_upstream_of_or_within myeloid cell homeostasis 17913918 Process
59287 GO:0007212 IMP acts_upstream_of_or_within dopamine receptor signaling pathway 27008863 Process
59287 GO:0007215 IMP acts_upstream_of_or_within glutamate receptor signaling pathway 24889619 Process
59287 GO:0007611 IMP acts_upstream_of_or_within learning or memory 19494151 Process
59287 GO:0022010 IMP acts_upstream_of_or_within central nervous system myelination 27008863 Process
59287 GO:0030534 IMP acts_upstream_of_or_within adult behavior 27008863 Process
59287 GO:0034205 IGI acts_upstream_of_or_within amyloid-beta formation 16371134 Process
59287 GO:0042098 IMP acts_upstream_of_or_within T cell proliferation 17913918 Process
59287 GO:0042982 IMP acts_upstream_of_or_within amyloid precursor protein metabolic process 21597003 Process
59287 GO:0042983 IMP acts_upstream_of_or_within amyloid precursor protein biosynthetic process 18201567 Process
59287 GO:0042986 IMP acts_upstream_of_or_within positive regulation of amyloid precursor protein biosynthetic process 23826707 Process
59287 GO:0050435 IMP acts_upstream_of_or_within amyloid-beta metabolic process 17913918 Process
59287 GO:0050673 IGI acts_upstream_of_or_within epithelial cell proliferation 17913918 Process
59287 GO:0050673 IMP acts_upstream_of_or_within epithelial cell proliferation 17913918 Process
59287 GO:0051402 IMP acts_upstream_of_or_within neuron apoptotic process 19494151 Process
59287 GO:0071277 IMP acts_upstream_of_or_within cellular response to calcium ion 24889619 Process
59287 GO:1900271 IMP acts_upstream_of_or_within regulation of long-term synaptic potentiation 24889619 Process
59287 GO:1990926 IMP acts_upstream_of_or_within short-term synaptic potentiation 24889619 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
59287 GO:0004175 IDA contributes_to endopeptidase activity 19457123 Function
59287 GO:0004175 IMP contributes_to endopeptidase activity 17913918 Function
59287 GO:0005515 IPI enables protein binding 15474363,19725872,21597003,21600962,23585889 Function
59287 GO:0042500 IGI contributes_to aspartic endopeptidase activity, intramembrane cleaving 16371134 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
59287 GO:0005764 IDA located_in lysosome 25592972 Component
59287 GO:0005783 IDA located_in endoplasmic reticulum 12646573,21187406 Component
59287 GO:0005794 IDA located_in Golgi apparatus 12646573 Component
59287 GO:0005886 IDA located_in plasma membrane 12646573,18201567,21187406 Component
59287 GO:0008021 IDA located_in synaptic vesicle 25438880 Component
59287 GO:0016020 IDA located_in membrane 11943765,15634781,15886206 Component
59287 GO:0032991 IDA part_of protein-containing complex 21597003 Component
59287 GO:0070765 IDA part_of gamma-secretase complex 16371134,16641999,20674680 Component