Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 6091
  • Symbol: ROBO1
  • Description: roundabout guidance receptor 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6091 GO:0002042 IMP involved_in cell migration involved in sprouting angiogenesis 19351956 Process
6091 GO:0006919 IMP involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process 18566128 Process
6091 GO:0007156 IDA involved_in homophilic cell adhesion via plasma membrane adhesion molecules 12504588 Process
6091 GO:0021836 IDA involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration 15207848 Process
6091 GO:0030336 IMP involved_in negative regulation of cell migration 26529257 Process
6091 GO:0030949 IMP involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway 21385766 Process
6091 GO:0033600 IMP involved_in negative regulation of mammary gland epithelial cell proliferation 18829537 Process
6091 GO:0035025 IMP involved_in positive regulation of Rho protein signal transduction 26529257 Process
6091 GO:0035385 IMP involved_in Roundabout signaling pathway 18829537,26529257 Process
6091 GO:0043406 IMP involved_in positive regulation of MAP kinase activity 21385766 Process
6091 GO:0050772 IDA involved_in positive regulation of axonogenesis 12504588 Process
6091 GO:0050925 IDA involved_in negative regulation of negative chemotaxis 11748139 Process
6091 GO:0070100 IMP involved_in negative regulation of chemokine-mediated signaling pathway 18829537 Process
6091 GO:1900748 IMP involved_in positive regulation of vascular endothelial growth factor signaling pathway 21385766 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6091 GO:0005515 IPI enables protein binding 12504588,15207848,17848514,26365803,26529257 Function
6091 GO:0008046 IDA enables axon guidance receptor activity 17848514 Function
6091 GO:0030275 IPI enables LRR domain binding 17848514 Function
6091 GO:0042802 IDA enables identical protein binding 12504588 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6091 GO:0005737 IDA located_in cytoplasm 18566128 Component
6091 GO:0005886 IDA located_in plasma membrane Component
6091 GO:0009986 IDA located_in cell surface 12504588 Component