Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 6262
  • Symbol: RYR2
  • Description: ryanodine receptor 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6262 GO:0002027 IMP involved_in regulation of heart rate 11159936,12919952,15197150 Process
6262 GO:0005513 IDA involved_in detection of calcium ion 10830164 Process
6262 GO:0006816 IDA involved_in calcium ion transport 17921453 Process
6262 GO:0010882 IMP involved_in regulation of cardiac muscle contraction by calcium ion signaling 17875969 Process
6262 GO:0014808 IMP involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 12919952 Process
6262 GO:0014850 IMP involved_in response to muscle activity 17875969 Process
6262 GO:0031000 IDA involved_in response to caffeine 17921453 Process
6262 GO:0035584 IDA involved_in calcium-mediated signaling using intracellular calcium source 17921453 Process
6262 GO:0035994 IMP involved_in response to muscle stretch 15105296 Process
6262 GO:0051209 IDA involved_in release of sequestered calcium ion into cytosol 12443530,17921453 Process
6262 GO:0051284 IDA involved_in positive regulation of sequestering of calcium ion 12443530,12919952 Process
6262 GO:0051775 IDA involved_in response to redox state 19226252 Process
6262 GO:0055117 IMP involved_in regulation of cardiac muscle contraction 11159936 Process
6262 GO:0060048 IMP involved_in cardiac muscle contraction 10830164 Process
6262 GO:0060402 IDA involved_in calcium ion transport into cytosol 17921453 Process
6262 GO:0071313 IDA involved_in cellular response to caffeine 12919952 Process
6262 GO:0072599 IDA involved_in establishment of protein localization to endoplasmic reticulum 12443530 Process
6262 GO:0097050 IMP involved_in type B pancreatic cell apoptotic process 15044459 Process
6262 GO:0098735 IMP involved_in positive regulation of the force of heart contraction 15105296 Process
6262 GO:0098904 IMP involved_in regulation of AV node cell action potential 17875969 Process
6262 GO:0098907 IMP involved_in regulation of SA node cell action potential 17875969 Process
6262 GO:0098910 IMP involved_in regulation of atrial cardiac muscle cell action potential 17875969 Process
6262 GO:0098911 IMP involved_in regulation of ventricular cardiac muscle cell action potential 17875969 Process
6262 GO:1901896 IDA involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity 12443530 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6262 GO:0005219 IDA enables ryanodine-sensitive calcium-release channel activity 17921453 Function
6262 GO:0005515 IPI enables protein binding 10830164,11237759,17921453,20195357,23233753 Function
6262 GO:0005516 IDA enables calmodulin binding 22067155,26164367,27516456 Function
6262 GO:0005516 IMP enables calmodulin binding 19220289 Function
6262 GO:0005516 IPI enables calmodulin binding 23040497 Function
6262 GO:0015278 IDA enables calcium-release channel activity 17921453 Function
6262 GO:0019899 IPI enables enzyme binding 16213210 Function
6262 GO:0034236 IDA enables protein kinase A catalytic subunit binding 10830164 Function
6262 GO:0034237 IDA enables protein kinase A regulatory subunit binding 10830164 Function
6262 GO:0042802 IPI enables identical protein binding 10830164 Function
6262 GO:0043924 IMP enables suramin binding 19220289 Function
6262 GO:0048763 IDA enables calcium-induced calcium release activity 17921453 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6262 GO:0016020 IDA located_in membrane 12443530 Component
6262 GO:0016529 IDA located_in sarcoplasmic reticulum 10830164,12919952 Component
6262 GO:0030018 IDA located_in Z disc 19131648 Component
6262 GO:0032991 IDA part_of protein-containing complex 18468998 Component
6262 GO:0034704 IDA part_of calcium channel complex 10830164,16213210 Component