Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 65018
  • Symbol: PINK1
  • Description: PTEN induced kinase 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
65018 GO:0000287 IDA enables magnesium ion binding 14607334 Function
65018 GO:0002020 IPI enables protease binding 21138942 Function
65018 GO:0004672 IMP enables protein kinase activity 25527497,32047033 Function
65018 GO:0004674 IDA enables protein serine/threonine kinase activity 14607334,17579517,19880420,24784582,25527291 Function
65018 GO:0005515 IPI enables protein binding 16632486,17579517,19229105,20153330,21177249,22078885,23933751..... Function
65018 GO:0005524 IDA enables ATP binding 14607334 Function
65018 GO:0010857 IDA enables calcium-dependent protein kinase activity 19880420 Function
65018 GO:0016301 IDA enables kinase activity 15824318 Function
65018 GO:0031625 IPI enables ubiquitin protein ligase binding 20798600 Function
65018 GO:0043422 IDA enables protein kinase B binding 21177249 Function
65018 GO:0044877 IMP enables protein-containing complex binding 24270810 Function
65018 GO:0055131 IPI enables C3HC4-type RING finger domain binding 19880420 Function
65018 GO:0106310 IMP enables protein serine kinase activity 32484300 Function
65018 GO:1904841 IPI enables TORC2 complex binding 21177249 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
65018 GO:0000422 IMP involved_in autophagy of mitochondrion 20798600,23933751,24896179 Process
65018 GO:0000423 IGI involved_in mitophagy 33406421 Process
65018 GO:0001934 IDA involved_in positive regulation of protein phosphorylation 25244949 Process
65018 GO:0002082 IDA involved_in regulation of oxidative phosphorylation 20871098 Process
65018 GO:0006468 IDA involved_in protein phosphorylation 14607334,21177249,25527291,32139798 Process
65018 GO:0006468 IMP involved_in protein phosphorylation 18957282,25527497 Process
65018 GO:0006979 IGI involved_in response to oxidative stress 24475098 Process
65018 GO:0007005 IMP involved_in mitochondrion organization 18560593 Process
65018 GO:0010821 IMP involved_in regulation of mitochondrion organization 21508222 Process
65018 GO:0016239 IMP involved_in positive regulation of macroautophagy 20871098 Process
65018 GO:0016242 IMP involved_in negative regulation of macroautophagy 19279012 Process
65018 GO:0016567 IMP involved_in protein ubiquitination 23933751 Process
65018 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 17579517,19880420 Process
65018 GO:0030097 IGI acts_upstream_of_or_within hemopoiesis 33406421 Process
65018 GO:0031396 IDA involved_in regulation of protein ubiquitination 19880420 Process
65018 GO:0031396 IMP involved_in regulation of protein ubiquitination 20871098,23212910 Process
65018 GO:0033138 IDA involved_in positive regulation of peptidyl-serine phosphorylation 21177249 Process
65018 GO:0033138 IMP involved_in positive regulation of peptidyl-serine phosphorylation 24660806 Process
65018 GO:0034599 IMP involved_in cellular response to oxidative stress 22764206 Process
65018 GO:0035556 IDA involved_in intracellular signal transduction 14607334 Process
65018 GO:0036289 IMP involved_in peptidyl-serine autophosphorylation 25527497 Process
65018 GO:0043123 IDA involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 19880420 Process
65018 GO:0043254 IDA involved_in regulation of protein-containing complex assembly 19880420 Process
65018 GO:0043524 IMP involved_in negative regulation of neuron apoptotic process 18560593 Process
65018 GO:0050821 IMP involved_in protein stabilization 19229105 Process
65018 GO:0051881 IGI involved_in regulation of mitochondrial membrane potential 24475098 Process
65018 GO:0051881 IMP involved_in regulation of mitochondrial membrane potential 18560593,21138942 Process
65018 GO:0071456 IMP involved_in cellular response to hypoxia 24553947 Process
65018 GO:0072655 IMP involved_in establishment of protein localization to mitochondrion 18957282,25527497 Process
65018 GO:0072656 IMP involved_in maintenance of protein location in mitochondrion 25527497 Process
65018 GO:0090200 IMP involved_in positive regulation of release of cytochrome c from mitochondria 19880420 Process
65018 GO:0090258 IMP involved_in negative regulation of mitochondrial fission 19279012 Process
65018 GO:0098779 IMP involved_in positive regulation of mitophagy in response to mitochondrial depolarization 20871098 Process
65018 GO:0099074 IMP involved_in mitochondrion to lysosome transport 24446486 Process
65018 GO:1900407 IMP involved_in regulation of cellular response to oxidative stress 24446486 Process
65018 GO:1901525 IMP involved_in negative regulation of mitophagy 19279012 Process
65018 GO:1902902 IMP involved_in negative regulation of autophagosome assembly 19279012 Process
65018 GO:1903214 IDA involved_in regulation of protein targeting to mitochondrion 25244949 Process
65018 GO:1903214 IGI involved_in regulation of protein targeting to mitochondrion 21508222 Process
65018 GO:1903214 IMP involved_in regulation of protein targeting to mitochondrion 23212910 Process
65018 GO:1903377 IDA involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 16632486 Process
65018 GO:1903384 IDA involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 21177249 Process
65018 GO:1903384 IMP involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 23261939 Process
65018 GO:1903751 IDA involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 17579517 Process
65018 GO:1903852 IMP involved_in positive regulation of cristae formation 19279012 Process
65018 GO:1903955 HMP involved_in positive regulation of protein targeting to mitochondrion 24270810 Process
65018 GO:2000377 IGI involved_in regulation of reactive oxygen species metabolic process 24475098 Process
65018 GO:2000377 IMP involved_in regulation of reactive oxygen species metabolic process 21138942 Process
65018 GO:2000378 IMP involved_in negative regulation of reactive oxygen species metabolic process 18560593 Process
65018 GO:2001243 IDA involved_in negative regulation of intrinsic apoptotic signaling pathway 15087508 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
65018 GO:0000785 IDA part_of chromatin 24798695 Component
65018 GO:0005634 IDA located_in nucleus 24798695 Component
65018 GO:0005737 IDA located_in cytoplasm 16702191 Component
65018 GO:0005739 IDA located_in mitochondrion 15087508,15824318,16702191,18957282,19229105,20798600,21138942..... Component
65018 GO:0005739 IGI located_in mitochondrion 21355049 Component
65018 GO:0005739 IMP located_in mitochondrion 24184327 Component
65018 GO:0005741 IDA located_in mitochondrial outer membrane 18687899,21426348 Component
65018 GO:0005741 IMP located_in mitochondrial outer membrane 25527497 Component
65018 GO:0005743 IDA located_in mitochondrial inner membrane 17579517,21426348 Component
65018 GO:0005758 IDA located_in mitochondrial intermembrane space 17579517,21426348 Component
65018 GO:0005783 IDA located_in endoplasmic reticulum 31536960 Component
65018 GO:0005829 IDA located_in cytosol 18957282,19229105,19880420,20798600,21138942,21426348,24798695..... Component
65018 GO:0005856 IDA located_in cytoskeleton 24798695 Component
65018 GO:0016020 IDA located_in membrane 24798695 Component
65018 GO:0030424 IDA located_in axon 16702191 Component
65018 GO:0044297 IDA located_in cell body 16702191 Component
65018 GO:0048471 IDA located_in perinuclear region of cytoplasm 16702191 Component
65018 GO:0097449 IDA located_in astrocyte projection 16702191 Component