Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 6591
• Symbol: SNAI2
• Description: snail family transcriptional repressor 2

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
6591	GO:0000122	IDA	involved_in	negative regulation of transcription by RNA polymerase II	10866665,11912130,15737616,16707493	Process
6591	GO:0000122	IMP	involved_in	negative regulation of transcription by RNA polymerase II	17984306,18663143	Process
6591	GO:0001649	IEP	involved_in	osteoblast differentiation	20128911	Process
6591	GO:0001837	IMP	involved_in	epithelial to mesenchymal transition	9182671,17984306	Process
6591	GO:0007219	IMP	involved_in	Notch signaling pathway	18663143	Process
6591	GO:0007605	IMP	involved_in	sensory perception of sound	12444107	Process
6591	GO:0010839	IDA	involved_in	negative regulation of keratinocyte proliferation	16707493	Process
6591	GO:0010957	IDA	involved_in	negative regulation of vitamin D biosynthetic process	18485278,19502595	Process
6591	GO:0014032	IMP	involved_in	neural crest cell development	12444107	Process
6591	GO:0030335	IMP	involved_in	positive regulation of cell migration	15314165	Process
6591	GO:0032331	IMP	involved_in	negative regulation of chondrocyte differentiation	19756381	Process
6591	GO:0032642	IMP	involved_in	regulation of chemokine production	21182836	Process
6591	GO:0033629	IDA	acts_upstream_of	negative regulation of cell adhesion mediated by integrin	16707493	Process
6591	GO:0035921	IMP	involved_in	desmosome disassembly	9182671	Process
6591	GO:0043473	IMP	involved_in	pigmentation	12444107	Process
6591	GO:0043518	IMP	involved_in	negative regulation of DNA damage response, signal transduction by p53 class mediator	15314165	Process
6591	GO:0045667	IMP	involved_in	regulation of osteoblast differentiation	19756381,21182836	Process
6591	GO:0070563	IDA	involved_in	negative regulation of vitamin D receptor signaling pathway	19502595	Process
6591	GO:0071364	IDA	involved_in	cellular response to epidermal growth factor stimulus	18716062	Process
6591	GO:0090090	IDA	involved_in	negative regulation of canonical Wnt signaling pathway	19502595	Process
6591	GO:0090090	IMP	involved_in	negative regulation of canonical Wnt signaling pathway	19756381	Process
6591	GO:1902230	IMP	involved_in	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	15314165	Process
6591	GO:2000810	IMP	involved_in	regulation of bicellular tight junction assembly	15314165	Process
6591	GO:2000811	IMP	involved_in	negative regulation of anoikis	17984306	Process

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
6591	GO:0000785	IDA	part_of	chromatin	16707493,19756381	Component
6591	GO:0005634	IDA	located_in	nucleus	10866665,25893292	Component

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
6591	GO:0000977	IDA	enables	RNA polymerase II transcription regulatory region sequence-specific DNA binding	11912130	Function
6591	GO:0001227	IDA	enables	DNA-binding transcription repressor activity, RNA polymerase II-specific	10866665,11912130,15737616,16707493,18663143	Function
6591	GO:0005515	IPI	enables	protein binding	25416956,32296183	Function
6591	GO:0043565	IDA	enables	sequence-specific DNA binding	10518215,10866665	Function
6591	GO:0070888	IDA	enables	E-box binding	11912130,15737616,16707493	Function
6591	GO:1990837	IDA	enables	sequence-specific double-stranded DNA binding	28473536	Function