Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 6622
  • Symbol: SNCA
  • Description: synuclein alpha

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6622 GO:0000149 IDA enables SNARE binding 20798282 Function
6622 GO:0000287 IDA enables magnesium ion binding 11850416 Function
6622 GO:0003779 IPI enables actin binding 18331289 Function
6622 GO:0005504 IDA NOT enables fatty acid binding 16687662 Function
6622 GO:0005507 IDA enables copper ion binding 21319811,21320589 Function
6622 GO:0005509 IDA enables calcium ion binding 11312271,11850416 Function
6622 GO:0005515 IPI enables protein binding 10319874,11943812,11956199,12044636,12059041,12958153,15207266..... Function
6622 GO:0005543 IDA enables phospholipid binding 17222866 Function
6622 GO:0008198 IDA enables ferrous iron binding 11850416 Function
6622 GO:0008270 IDA enables zinc ion binding 11850416 Function
6622 GO:0008289 EXP enables lipid binding 11286556,20524659,22315227 Function
6622 GO:0008289 IDA enables lipid binding 8901511 Function
6622 GO:0016491 IDA enables oxidoreductase activity 21320589 Function
6622 GO:0019894 IPI enables kinesin binding 16176937 Function
6622 GO:0030544 IPI enables Hsp70 protein binding 18975920 Function
6622 GO:0042393 IDA enables histone binding 16959795 Function
6622 GO:0042802 IDA enables identical protein binding 24936070,25561023 Function
6622 GO:0042802 IPI enables identical protein binding 15502874,16330551,16764865,18614564,19745811,19875982,21443877..... Function
6622 GO:0043014 IPI enables alpha-tubulin binding 11698390 Function
6622 GO:0043027 IDA enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process 10818098 Function
6622 GO:0048156 IDA enables tau protein binding 17408955,21127069 Function
6622 GO:0051219 IDA enables phosphoprotein binding 21127069 Function
6622 GO:0060090 EXP enables molecular adaptor activity 11286556 Function
6622 GO:0060961 IDA NOT enables phospholipase D inhibitor activity 19146388 Function
6622 GO:0070840 IPI enables dynein complex binding 16176937 Function
6622 GO:1903136 IMP enables cuprous ion binding 25495902 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6622 GO:0001921 IDA involved_in positive regulation of receptor recycling 18980610 Process
6622 GO:0006919 IDA involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process 21050448 Process
6622 GO:0010040 IDA involved_in response to iron(II) ion 11850416 Process
6622 GO:0010517 IDA involved_in regulation of phospholipase activity 15641770 Process
6622 GO:0010642 IDA involved_in negative regulation of platelet-derived growth factor receptor signaling pathway 12239163 Process
6622 GO:0016079 IDA involved_in synaptic vesicle exocytosis 28288128 Process
6622 GO:0016082 IMP involved_in synaptic vesicle priming 30404828 Process
6622 GO:0022898 IGI involved_in regulation of transmembrane transporter activity 18331289 Process
6622 GO:0031115 IDA involved_in negative regulation of microtubule polymerization 21127069 Process
6622 GO:0031623 IDA involved_in receptor internalization 18980610 Process
6622 GO:0031648 IDA involved_in protein destabilization 21320589 Process
6622 GO:0032026 IDA involved_in response to magnesium ion 11850416 Process
6622 GO:0032410 IDA involved_in negative regulation of transporter activity 16882008 Process
6622 GO:0032496 IDA involved_in response to lipopolysaccharide 12406186 Process
6622 GO:0032769 IDA involved_in negative regulation of monooxygenase activity 11943812 Process
6622 GO:0034341 IDA involved_in response to type II interferon 19157893 Process
6622 GO:0035493 IDA involved_in SNARE complex assembly 20798282 Process
6622 GO:0035543 IDA involved_in positive regulation of SNARE complex assembly 20798282 Process
6622 GO:0043066 IMP involved_in negative regulation of apoptotic process 10818098 Process
6622 GO:0043154 IMP involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 10818098 Process
6622 GO:0045807 IDA involved_in positive regulation of endocytosis 18980610 Process
6622 GO:0045920 IMP involved_in negative regulation of exocytosis 12239163 Process
6622 GO:0045921 IMP involved_in positive regulation of exocytosis 30404828 Process
6622 GO:0050729 IDA involved_in positive regulation of inflammatory response 25533483 Process
6622 GO:0051179 EXP involved_in localization 11286556 Process
6622 GO:0051262 IDA involved_in protein tetramerization 21841800 Process
6622 GO:0051281 IDA involved_in positive regulation of release of sequestered calcium ion into cytosol 15641770 Process
6622 GO:0051585 IDA involved_in negative regulation of dopamine uptake involved in synaptic transmission 12958153 Process
6622 GO:0051612 IDA involved_in negative regulation of serotonin uptake 16882008 Process
6622 GO:0051621 IGI involved_in regulation of norepinephrine uptake 18331289 Process
6622 GO:0051622 IDA involved_in negative regulation of norepinephrine uptake 17156375 Process
6622 GO:0055074 IDA NOT involved_in calcium ion homeostasis 12239163 Process
6622 GO:0060732 IDA involved_in positive regulation of inositol phosphate biosynthetic process 15641770 Process
6622 GO:0070495 IDA involved_in negative regulation of thrombin-activated receptor signaling pathway 12239163 Process
6622 GO:0070555 IDA involved_in response to interleukin-1 12406186 Process
6622 GO:0071280 IDA involved_in cellular response to copper ion 21320589 Process
6622 GO:0071902 IDA involved_in positive regulation of protein serine/threonine kinase activity 21127069 Process
6622 GO:1901215 IDA involved_in negative regulation of neuron death 15863497 Process
6622 GO:1901216 IDA involved_in positive regulation of neuron death 25533483 Process
6622 GO:1903284 IDA involved_in positive regulation of glutathione peroxidase activity 23507046 Process
6622 GO:1903285 IDA involved_in positive regulation of hydrogen peroxide catabolic process 23507046 Process
6622 GO:1904715 IMP involved_in negative regulation of chaperone-mediated autophagy 20697033 Process
6622 GO:1905606 IGI involved_in regulation of presynapse assembly 25533483 Process
6622 GO:1990000 EXP involved_in amyloid fibril formation 8901511 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6622 GO:0005576 IDA located_in extracellular region 15863497 Component
6622 GO:0005615 IDA located_in extracellular space 24936070 Component
6622 GO:0005634 IDA located_in nucleus 12406186,16959795,17408955,24936070 Component
6622 GO:0005737 IDA located_in cytoplasm 12406186,12958153,15863497,16959795,17408955,23983262,24403142..... Component
6622 GO:0005829 IDA located_in cytosol 8248242,24936070,31034892 Component
6622 GO:0005886 IDA located_in plasma membrane 12958153,15641770,17222866 Component
6622 GO:0005938 IDA located_in cell cortex 19157893 Component
6622 GO:0015629 IDA located_in actin cytoskeleton 17408955 Component
6622 GO:0016020 IDA located_in membrane 24936070 Component
6622 GO:0016234 IDA located_in inclusion body 17222866,20039155 Component
6622 GO:0030424 IDA located_in axon 12958153 Component
6622 GO:0030426 IDA located_in growth cone 12958153 Component
6622 GO:0031092 IDA colocalizes_with platelet alpha granule membrane 12239163 Component
6622 GO:0032991 IMP part_of protein-containing complex 31034892 Component
6622 GO:0048471 IDA located_in perinuclear region of cytoplasm 20039155 Component
6622 GO:0099512 IDA located_in supramolecular fiber 17222866,18346205,23507046 Component