Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 66725
  • Symbol: Lrrk2
  • Description: leucine-rich repeat kinase 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
66725 GO:0001933 IMP involved_in negative regulation of protein phosphorylation 24464040 Process
66725 GO:0006468 IDA acts_upstream_of_or_within protein phosphorylation 27798112 Process
66725 GO:0006468 IMP acts_upstream_of_or_within protein phosphorylation 27798112 Process
66725 GO:0006468 IMP involved_in protein phosphorylation 28720718 Process
66725 GO:0006606 IDA acts_upstream_of_or_within protein import into nucleus 27798112 Process
66725 GO:0006606 IMP acts_upstream_of_or_within protein import into nucleus 27798112 Process
66725 GO:0007029 IMP involved_in endoplasmic reticulum organization 25201882 Process
66725 GO:0007030 IGI acts_upstream_of_or_within Golgi organization 24510904 Process
66725 GO:0008104 IMP involved_in protein localization 24464040 Process
66725 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 24427314 Process
66725 GO:0010508 IMP involved_in positive regulation of autophagy 20457918 Process
66725 GO:0010738 IMP involved_in regulation of protein kinase A signaling 24464040 Process
66725 GO:0032436 IMP involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 20457918 Process
66725 GO:0035556 IMP involved_in intracellular signal transduction 24464040 Process
66725 GO:0035564 IMP involved_in regulation of kidney size 20457918 Process
66725 GO:0035641 IMP involved_in locomotory exploration behavior 24464040 Process
66725 GO:0051966 IMP involved_in regulation of synaptic transmission, glutamatergic 24464040 Process
66725 GO:0060079 IMP involved_in excitatory postsynaptic potential 24464040 Process
66725 GO:0060159 IMP involved_in regulation of dopamine receptor signaling pathway 24464040 Process
66725 GO:0060628 IMP involved_in regulation of ER to Golgi vesicle-mediated transport 25201882 Process
66725 GO:0060828 IPI involved_in regulation of canonical Wnt signaling pathway 22899650 Process
66725 GO:0061001 IGI involved_in regulation of dendritic spine morphogenesis 24464040 Process
66725 GO:0070973 IMP involved_in protein localization to endoplasmic reticulum exit site 25201882 Process
66725 GO:0090394 IMP involved_in negative regulation of excitatory postsynaptic potential 21307259 Process
66725 GO:1900242 IDA involved_in regulation of synaptic vesicle endocytosis 25501810 Process
66725 GO:1900242 IMP involved_in regulation of synaptic vesicle endocytosis 25501810 Process
66725 GO:1902803 IMP involved_in regulation of synaptic vesicle transport 21307259 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
66725 GO:0004672 IDA enables protein kinase activity 24510904 Function
66725 GO:0004674 IDA enables protein serine/threonine kinase activity 27798112 Function
66725 GO:0004674 IMP enables protein serine/threonine kinase activity 27798112,28720718 Function
66725 GO:0005515 IPI enables protein binding 21048939,21307259,21390248,22363216,22423108,22639965,22899650..... Function
66725 GO:0031267 IPI enables small GTPase binding 21048939 Function
66725 GO:0042802 IPI enables identical protein binding 21390248,22952686,27357661 Function
66725 GO:0051018 IPI enables protein kinase A binding 24464040 Function
66725 GO:1904713 IPI enables beta-catenin destruction complex binding 22899650 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
66725 GO:0005737 IDA located_in cytoplasm 27273569 Component
66725 GO:0005741 IDA located_in mitochondrial outer membrane 17120249 Component
66725 GO:0005743 IDA located_in mitochondrial inner membrane 17120249 Component
66725 GO:0005759 IDA located_in mitochondrial matrix 17120249 Component
66725 GO:0005764 IDA located_in lysosome 17120249 Component
66725 GO:0005768 IDA located_in endosome 17120249 Component
66725 GO:0005783 IDA located_in endoplasmic reticulum 17120249 Component
66725 GO:0005794 IDA located_in Golgi apparatus 17120249 Component
66725 GO:0005802 IDA located_in trans-Golgi network 17341485,24510904 Component
66725 GO:0005886 IDA located_in plasma membrane 17341485 Component
66725 GO:0008021 IDA located_in synaptic vesicle 17341485 Component
66725 GO:0030425 IDA located_in dendrite 24464040 Component
66725 GO:0031410 IDA located_in cytoplasmic vesicle 17120249 Component
66725 GO:0045121 IDA located_in membrane raft 17341485 Component
66725 GO:0045202 IDA located_in synapse 22423108 Component
66725 GO:0070971 IDA located_in endoplasmic reticulum exit site 25201882 Component
66725 GO:0098978 IDA is_active_in glutamatergic synapse 25501810 Component
66725 GO:0098978 IMP is_active_in glutamatergic synapse 25501810 Component
66725 GO:0099523 IDA is_active_in presynaptic cytosol 17341485 Component
66725 GO:1990904 IDA part_of ribonucleoprotein complex 24427314 Component
66725 GO:1990909 IDA part_of Wnt signalosome 22899650 Component