Gene Ontology

Gene Info

• Species: Mouse (Mus musculus)
• GeneID: 69847
• Symbol: Wnk4
• Description: WNK lysine deficient protein kinase 4

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
69847	GO:0002021	IMP	involved_in	response to dietary excess	22550170,24761002,28314693	Process
69847	GO:0003096	IDA	involved_in	renal sodium ion transport	14608358	Process
69847	GO:0006468	IGI	involved_in	protein phosphorylation	28743496	Process
69847	GO:0006468	IMP	involved_in	protein phosphorylation	22114204,24655003,24761002,31736353,31786261	Process
69847	GO:0006469	IMP	involved_in	negative regulation of protein kinase activity	30765526	Process
69847	GO:0006821	IDA	acts_upstream_of_or_within	chloride transport	14769928	Process
69847	GO:0006954	IMP	involved_in	inflammatory response	31786261	Process
69847	GO:0007165	IMP	involved_in	signal transduction	21486947	Process
69847	GO:0008104	IDA	acts_upstream_of_or_within	protein localization	12515852,12671053	Process
69847	GO:0008217	IMP	involved_in	regulation of blood pressure	16964266,17360470,17488636,19633012	Process
69847	GO:0009410	IGI	involved_in	response to xenobiotic stimulus	24039833	Process
69847	GO:0010467	IGI	involved_in	gene expression	28743496	Process
69847	GO:0010467	IMP	involved_in	gene expression	22114204,22550170,23576762,24206662,24655003,28314693,28365586.....	Process
69847	GO:0030644	IMP	involved_in	intracellular chloride ion homeostasis	30765526	Process
69847	GO:0032147	IDA	involved_in	activation of protein kinase activity	28096417	Process
69847	GO:0035725	IMP	involved_in	sodium ion transmembrane transport	24655003,25113964,28365586,31736353	Process
69847	GO:0035932	IMP	involved_in	aldosterone secretion	22550170	Process
69847	GO:0042116	IMP	involved_in	macrophage activation	31786261	Process
69847	GO:0045859	IMP	involved_in	regulation of protein kinase activity	29921588	Process
69847	GO:0050801	IMP	involved_in	monoatomic ion homeostasis	23576762	Process
69847	GO:0055074	IMP	involved_in	calcium ion homeostasis	31496133	Process
69847	GO:0070294	IMP	involved_in	renal sodium ion absorption	16964266,17488636,19633012	Process
69847	GO:0070371	IMP	involved_in	ERK1 and ERK2 cascade	22114204	Process
69847	GO:0070528	IDA	involved_in	protein kinase C signaling	28096417	Process
69847	GO:0071466	IMP	involved_in	cellular response to xenobiotic stimulus	31496133	Process
69847	GO:0071805	IMP	involved_in	potassium ion transmembrane transport	28365586	Process
69847	GO:0090188	IMP	acts_upstream_of_or_within	negative regulation of pancreatic juice secretion	21317537	Process
69847	GO:1903077	IDA	involved_in	negative regulation of protein localization to plasma membrane	17673510	Process
69847	GO:1903764	IMP	involved_in	regulation of potassium ion export across plasma membrane	16964266	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
69847	GO:0004674	IMP	enables	protein serine/threonine kinase activity	21486947	Function
69847	GO:0005515	IPI	enables	protein binding	17360471,21670282,23576762,24434184,24821705,25250572,25313067.....	Function
69847	GO:0008200	IDA	enables	ion channel inhibitor activity	14608358	Function
69847	GO:0031404	IMP	enables	chloride ion binding	30765526	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
69847	GO:0005737	IDA	located_in	cytoplasm	14769928	Component
69847	GO:0005923	IDA	located_in	bicellular tight junction	11498583	Component
69847	GO:0032991	IDA	part_of	protein-containing complex	25113964	Component
69847	GO:0044297	IMP	is_active_in	cell body	31736353	Component