Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 7157
• Symbol: TP53
• Description: tumor protein p53

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7157	GO:0000122	IDA	involved_in	negative regulation of transcription by RNA polymerase II	10329733	Process
7157	GO:0002244	IMP	involved_in	hematopoietic progenitor cell differentiation	30146126	Process
7157	GO:0006289	IMP	involved_in	nucleotide-excision repair	7663514	Process
7157	GO:0006355	IDA	involved_in	regulation of DNA-templated transcription	7587074	Process
7157	GO:0006355	IMP	involved_in	regulation of DNA-templated transcription	25417702	Process
7157	GO:0006914	IMP	involved_in	autophagy	23629966	Process
7157	GO:0006974	IDA	acts_upstream_of_or_within	DNA damage response	14744935	Process
7157	GO:0006974	IDA	involved_in	DNA damage response	15710329,17938203	Process
7157	GO:0006974	IMP	involved_in	DNA damage response	24356969	Process
7157	GO:0006977	IMP	involved_in	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	16213212	Process
7157	GO:0006978	IDA	involved_in	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	16213212	Process
7157	GO:0006978	IMP	involved_in	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	7958916,16479015	Process
7157	GO:0006983	IDA	acts_upstream_of_or_within	ER overload response	14744935	Process
7157	GO:0007265	IEP	involved_in	Ras protein signal transduction	9054499	Process
7157	GO:0008104	IDA	involved_in	protein localization	16507995	Process
7157	GO:0008285	IDA	involved_in	negative regulation of cell population proliferation	22783376	Process
7157	GO:0008285	IMP	involved_in	negative regulation of cell population proliferation	12730672	Process
7157	GO:0009299	IMP	involved_in	mRNA transcription	16479015	Process
7157	GO:0010332	IMP	involved_in	response to gamma radiation	7958916	Process
7157	GO:0010628	IDA	involved_in	positive regulation of gene expression	15314173,20332243,26100857	Process
7157	GO:0010628	IMP	acts_upstream_of_or_within	positive regulation of gene expression	30089260	Process
7157	GO:0010628	IMP	involved_in	positive regulation of gene expression	19160485	Process
7157	GO:0016032	IMP	involved_in	viral process	22574148	Process
7157	GO:0030308	IMP	involved_in	negative regulation of cell growth	8986812	Process
7157	GO:0030330	IDA	involved_in	DNA damage response, signal transduction by p53 class mediator	15149599	Process
7157	GO:0030330	IMP	involved_in	DNA damage response, signal transduction by p53 class mediator	20160708	Process
7157	GO:0031571	IMP	involved_in	mitotic G1 DNA damage checkpoint signaling	7958916	Process
7157	GO:0033209	IGI	involved_in	tumor necrosis factor-mediated signaling pathway	22499991	Process
7157	GO:0034644	IDA	involved_in	cellular response to UV	16213212,23629966	Process
7157	GO:0036003	IDA	involved_in	positive regulation of transcription from RNA polymerase II promoter in response to stress	30089260	Process
7157	GO:0042149	IDA	acts_upstream_of_or_within	cellular response to glucose starvation	14744935	Process
7157	GO:0042149	IDA	involved_in	cellular response to glucose starvation	21471221	Process
7157	GO:0042771	IDA	acts_upstream_of_or_within	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	14654789,14744935	Process
7157	GO:0042771	IDA	involved_in	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17403783	Process
7157	GO:0042771	IMP	involved_in	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	16213212	Process
7157	GO:0042981	IDA	acts_upstream_of_or_within	regulation of apoptotic process	14744935	Process
7157	GO:0043065	IDA	involved_in	positive regulation of apoptotic process	12667443,15565177,20959462	Process
7157	GO:0043066	IGI	involved_in	negative regulation of apoptotic process	12203124,12433990	Process
7157	GO:0043066	IMP	involved_in	negative regulation of apoptotic process	20124405	Process
7157	GO:0045815	IDA	involved_in	transcription initiation-coupled chromatin remodeling	16322561	Process
7157	GO:0045892	IDA	involved_in	negative regulation of DNA-templated transcription	9271120,24051492	Process
7157	GO:0045892	IMP	involved_in	negative regulation of DNA-templated transcription	23629966	Process
7157	GO:0045893	IDA	involved_in	positive regulation of DNA-templated transcription	16322561,17403783,20378837	Process
7157	GO:0045893	IMP	involved_in	positive regulation of DNA-templated transcription	20096447	Process
7157	GO:0045899	IDA	involved_in	positive regulation of RNA polymerase II transcription preinitiation complex assembly	24289924	Process
7157	GO:0045944	IDA	acts_upstream_of_or_within	positive regulation of transcription by RNA polymerase II	17599062	Process
7157	GO:0045944	IDA	involved_in	positive regulation of transcription by RNA polymerase II	11672523,17145718,17310983,18549481,20959462,24652652.....	Process
7157	GO:0045944	IGI	acts_upstream_of_or_within	positive regulation of transcription by RNA polymerase II	16061649	Process
7157	GO:0045944	IMP	involved_in	positive regulation of transcription by RNA polymerase II	17146433,24356969	Process
7157	GO:0046677	IEP	involved_in	response to antibiotic	20810912	Process
7157	GO:0048147	IMP	involved_in	negative regulation of fibroblast proliferation	10962037	Process
7157	GO:0048539	IMP	involved_in	bone marrow development	30146126	Process
7157	GO:0051726	IDA	involved_in	regulation of cell cycle	15149599	Process
7157	GO:0051726	IGI	involved_in	regulation of cell cycle	12203124,12433990	Process
7157	GO:0051726	IMP	involved_in	regulation of cell cycle	7958916	Process
7157	GO:0051974	IDA	involved_in	negative regulation of telomerase activity	10597287	Process
7157	GO:0060218	IMP	involved_in	hematopoietic stem cell differentiation	30146126	Process
7157	GO:0065003	IDA	involved_in	protein-containing complex assembly	12915590	Process
7157	GO:0071456	IEP	involved_in	cellular response to hypoxia	20810912	Process
7157	GO:0071466	IEP	involved_in	cellular response to xenobiotic stimulus	20810912	Process
7157	GO:0071479	IMP	involved_in	cellular response to ionizing radiation	20160708	Process
7157	GO:0071480	IDA	involved_in	cellular response to gamma radiation	16213212	Process
7157	GO:0072331	IDA	involved_in	signal transduction by p53 class mediator	15314173	Process
7157	GO:0072332	IMP	involved_in	intrinsic apoptotic signaling pathway by p53 class mediator	12172011,16322561,17310983	Process
7157	GO:0072717	IDA	involved_in	cellular response to actinomycin D	15314173	Process
7157	GO:0090200	IDA	involved_in	positive regulation of release of cytochrome c from mitochondria	14963330	Process
7157	GO:0090398	IMP	involved_in	cellular senescence	12080348	Process
7157	GO:0090399	IMP	involved_in	replicative senescence	19951988	Process
7157	GO:0090403	IMP	involved_in	oxidative stress-induced premature senescence	19951988	Process
7157	GO:0097252	IDA	involved_in	oligodendrocyte apoptotic process	7720704	Process
7157	GO:1900119	IMP	involved_in	positive regulation of execution phase of apoptosis	14985081	Process
7157	GO:1902749	IMP	acts_upstream_of_negative_effect	regulation of cell cycle G2/M phase transition	10962037	Process
7157	GO:1902895	IDA	involved_in	positive regulation of miRNA transcription	20546595	Process
7157	GO:1902895	IGI	involved_in	positive regulation of miRNA transcription	22499991	Process
7157	GO:1902895	IMP	involved_in	positive regulation of miRNA transcription	22578566	Process
7157	GO:1903451	IDA	involved_in	negative regulation of G1 to G0 transition	15314173	Process
7157	GO:1903451	IMP	involved_in	negative regulation of G1 to G0 transition	21471221	Process
7157	GO:1905856	IMP	involved_in	negative regulation of pentose-phosphate shunt	21336310	Process
7157	GO:2000379	IMP	involved_in	positive regulation of reactive oxygen species metabolic process	20160708	Process
7157	GO:2000774	IDA	involved_in	positive regulation of cellular senescence	29474172	Process
7157	GO:2001244	IMP	involved_in	positive regulation of intrinsic apoptotic signaling pathway	14963330,27031958	Process

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7157	GO:0000785	IDA	part_of	chromatin	15710329,17805299,22521434,23629966,24289924	Component
7157	GO:0000785	IMP	part_of	chromatin	30089260	Component
7157	GO:0005634	IDA	located_in	nucleus	7720704,14744935,14963330,16322561,16507995,17403783,18756595,.....	Component
7157	GO:0005634	IMP	located_in	nucleus	16479015	Component
7157	GO:0005654	IDA	located_in	nucleoplasm	11080164,12915590	Component
7157	GO:0005667	IGI	part_of	transcription regulator complex	17145718	Component
7157	GO:0005730	IDA	located_in	nucleolus	12080348	Component
7157	GO:0005737	IDA	located_in	cytoplasm	7720704,14744935,16131611,19011621,20096447,20810912,21597459,.....	Component
7157	GO:0005737	IMP	located_in	cytoplasm	16479015	Component
7157	GO:0005739	IDA	located_in	mitochondrion	12667443,24101517,25168243	Component
7157	GO:0005813	IDA	located_in	centrosome	28842590	Component
7157	GO:0005829	IDA	located_in	cytosol	14963330,24101517	Component
7157	GO:0016363	IDA	located_in	nuclear matrix	11080164	Component
7157	GO:0016604	IDA	colocalizes_with	nuclear body	10360174	Component
7157	GO:0016605	IDA	located_in	PML body	12006491,22869143	Component
7157	GO:0017053	IPI	part_of	transcription repressor complex	8875929,18677113	Component
7157	GO:0032991	IDA	part_of	protein-containing complex	9529249,17310983	Component
7157	GO:0032991	IMP	part_of	protein-containing complex	15629713	Component

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7157	GO:0000976	IDA	enables	transcription cis-regulatory region binding	15710329,17996705	Function
7157	GO:0000978	IDA	enables	RNA polymerase II cis-regulatory region sequence-specific DNA binding	22578566,24289924	Function
7157	GO:0000981	IDA	enables	DNA-binding transcription factor activity, RNA polymerase II-specific	17310983,24289924,24652652	Function
7157	GO:0000987	IDA	enables	cis-regulatory region sequence-specific DNA binding	10329733	Function
7157	GO:0001046	IDA	enables	core promoter sequence-specific DNA binding	23629966	Function
7157	GO:0001094	IPI	enables	TFIID-class transcription factor complex binding	24289924	Function
7157	GO:0001227	IDA	enables	DNA-binding transcription repressor activity, RNA polymerase II-specific	10329733	Function
7157	GO:0001228	IDA	enables	DNA-binding transcription activator activity, RNA polymerase II-specific	12609999,17145718,17146433,22578566	Function
7157	GO:0002020	IPI	enables	protease binding	11923872	Function
7157	GO:0002039	IPI	enables	p53 binding	25417702	Function
7157	GO:0003677	IDA	enables	DNA binding	15358771	Function
7157	GO:0003677	IMP	enables	DNA binding	2144364,15629713	Function
7157	GO:0003682	IDA	enables	chromatin binding	16322561,17599062	Function
7157	GO:0003700	IDA	enables	DNA-binding transcription factor activity	7587074,18549481	Function
7157	GO:0003700	IMP	enables	DNA-binding transcription factor activity	16479015	Function
7157	GO:0003730	IDA	enables	mRNA 3'-UTR binding	16213212	Function
7157	GO:0005507	IDA	enables	copper ion binding	7824276	Function
7157	GO:0019899	IPI	enables	enzyme binding	17805299	Function
7157	GO:0030971	IPI	enables	receptor tyrosine kinase binding	23027130	Function
7157	GO:0031625	EXP	enables	ubiquitin protein ligase binding	8875929	Function
7157	GO:0031625	IPI	enables	ubiquitin protein ligase binding	8875929	Function
7157	GO:0036310	IDA	enables	ATP-dependent DNA/DNA annealing activity	8183576	Function
7157	GO:0042802	IPI	enables	identical protein binding	10876243,14759370,14985081,15629713,16291740,16461914,17612295.....	Function
7157	GO:0042826	IPI	enables	histone deacetylase binding	23629966	Function
7157	GO:0043621	IPI	enables	protein self-association	14985081	Function
7157	GO:0046982	IPI	enables	protein heterodimerization activity	10837489	Function
7157	GO:0051087	IPI	enables	protein-folding chaperone binding	15358771,18086682	Function
7157	GO:0051721	IPI	enables	protein phosphatase 2A binding	17245430	Function
7157	GO:0061629	IPI	enables	RNA polymerase II-specific DNA-binding transcription factor binding	15705871,18549481,19505873,23329847	Function
7157	GO:0071889	EXP	enables	14-3-3 protein binding	20206173	Function
7157	GO:0097718	IPI	enables	disordered domain specific binding	15629713	Function
7157	GO:0140296	IPI	enables	general transcription initiation factor binding	15053879	Function
7157	GO:0140677	EXP	enables	molecular function activator activity	14759370,16793543	Function
7157	GO:0140677	IPI	enables	molecular function activator activity	7559631	Function
7157	GO:1990841	IDA	enables	promoter-specific chromatin binding	20725088,24356969	Function
7157	GO:0005515	IPI	enables	protein binding	1465435,7663514,7799929,8207801,8344494,8675009,8875926,887592.....	Function