Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 7428
  • Symbol: VHL
  • Description: von Hippel-Lindau tumor suppressor

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7428 GO:0003711 IDA enables transcription elongation factor activity 7660122 Function
7428 GO:0005515 IPI enables protein binding 7660122,11292862,11641274,11739384,12004076,12032852,12050673,..... Function
7428 GO:0019899 IPI enables enzyme binding 11641274 Function
7428 GO:0060090 EXP enables molecular adaptor activity 10205047,12004076 Function
7428 GO:0140297 IPI enables DNA-binding transcription factor binding 11641274 Function
7428 GO:1990756 IDA enables ubiquitin ligase-substrate adaptor activity 24899725 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7428 GO:0005654 IDA located_in nucleoplasm Component
7428 GO:0043232 EXP is_active_in intracellular non-membrane-bounded organelle 14963040 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7428 GO:0006355 IMP involved_in regulation of DNA-templated transcription 15824735 Process
7428 GO:0008285 IDA involved_in negative regulation of cell population proliferation 23338840 Process
7428 GO:0008285 IMP involved_in negative regulation of cell population proliferation 23338840 Process
7428 GO:0009968 EXP involved_in negative regulation of signal transduction 23338840 Process
7428 GO:0010468 EXP involved_in regulation of gene expression 15824735 Process
7428 GO:0010468 IDA involved_in regulation of gene expression 17973242,23338840 Process
7428 GO:0010468 IEP involved_in regulation of gene expression 15824735,17973242 Process
7428 GO:0010507 IDA involved_in negative regulation of autophagy 30902965 Process
7428 GO:0010629 IMP involved_in negative regulation of gene expression 23338840 Process
7428 GO:0016567 IDA involved_in protein ubiquitination 24899725 Process
7428 GO:0016567 IMP involved_in protein ubiquitination 12169691 Process
7428 GO:0034244 IDA involved_in negative regulation of transcription elongation by RNA polymerase II 7660122 Process
7428 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 17973242 Process
7428 GO:0046426 IMP involved_in negative regulation of receptor signaling pathway via JAK-STAT 23338840 Process
7428 GO:0061428 IDA involved_in negative regulation of transcription from RNA polymerase II promoter in response to hypoxia 11641274 Process
7428 GO:0061912 IMP involved_in selective autophagy 30902965 Process
7428 GO:1900037 EXP involved_in regulation of cellular response to hypoxia 10205047 Process
7428 GO:1990000 EXP involved_in amyloid fibril formation 34431623 Process
7428 GO:1990000 IDA involved_in amyloid fibril formation 34431623 Process