Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 7498
• Symbol: XDH
• Description: xanthine dehydrogenase

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7498	GO:0000255	IDA	involved_in	allantoin metabolic process	1619276	Process
7498	GO:0001933	IDA	involved_in	negative regulation of protein phosphorylation	18386220	Process
7498	GO:0001937	IDA	involved_in	negative regulation of endothelial cell proliferation	18386220	Process
7498	GO:0006148	IDA	involved_in	inosine catabolic process	1619276	Process
7498	GO:0006149	IDA	involved_in	deoxyinosine catabolic process	1619276	Process
7498	GO:0006196	IDA	involved_in	AMP catabolic process	1619276	Process
7498	GO:0006204	IDA	involved_in	IMP catabolic process	1619276	Process
7498	GO:0006919	IDA	involved_in	activation of cysteine-type endopeptidase activity involved in apoptotic process	18386220	Process
7498	GO:0009114	IDA	involved_in	hypoxanthine catabolic process	1619276	Process
7498	GO:0009115	IDA	involved_in	xanthine catabolic process	8670112,17301077	Process
7498	GO:0010629	IDA	involved_in	negative regulation of gene expression	18386220	Process
7498	GO:0045602	IDA	involved_in	negative regulation of endothelial cell differentiation	18386220	Process
7498	GO:0051898	IDA	involved_in	negative regulation of protein kinase B signaling	18386220	Process
7498	GO:1900745	IDA	involved_in	positive regulation of p38MAPK cascade	18386220	Process
7498	GO:1900747	IDA	involved_in	negative regulation of vascular endothelial growth factor signaling pathway	18386220	Process
7498	GO:2000379	IDA	involved_in	positive regulation of reactive oxygen species metabolic process	18386220	Process
7498	GO:2001213	IDA	involved_in	negative regulation of vasculogenesis	18386220	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7498	GO:0004854	IDA	enables	xanthine dehydrogenase activity	8670112	Function
7498	GO:0004855	IDA	enables	xanthine oxidase activity	8670112,17301077	Function
7498	GO:0005515	IPI	enables	protein binding	32296183	Function
7498	GO:0042803	IPI	enables	protein homodimerization activity	17301077	Function
7498	GO:0043546	IDA	enables	molybdopterin cofactor binding	17301077	Function
7498	GO:0050660	IDA	enables	flavin adenine dinucleotide binding	17301077	Function
7498	GO:0051537	IDA	enables	2 iron, 2 sulfur cluster binding	17301077	Function
7498	GO:0070674	IDA	enables	hypoxanthine dehydrogenase activity	1619276	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7498	GO:0005615	HDA	located_in	extracellular space	16502470	Component
7498	GO:0005829	IDA	is_active_in	cytosol	1619276	Component