Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 8301
  • Symbol: PICALM
  • Description: phosphatidylinositol binding clathrin assembly protein

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8301 GO:0000149 IDA enables SNARE binding 22118466 Function
8301 GO:0005515 IPI enables protein binding 16262731,16491119,22118466,22829078,23382074,26496610,35044719..... Function
8301 GO:0030276 IDA enables clathrin binding 10436022,16262731 Function
8301 GO:0031267 IPI enables small GTPase binding 26005850 Function
8301 GO:0032050 IDA enables clathrin heavy chain binding 10436022 Function
8301 GO:0045296 HDA enables cadherin binding 25468996 Function
8301 GO:0048156 IPI enables tau protein binding 23589030 Function
8301 GO:0050750 IPI enables low-density lipoprotein particle receptor binding 26005850 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8301 GO:0005634 IDA located_in nucleus 16491119 Component
8301 GO:0005769 IDA located_in early endosome 26005850 Component
8301 GO:0005886 IDA located_in plasma membrane 16262731 Component
8301 GO:0005905 IDA located_in clathrin-coated pit 10436022 Component
8301 GO:0005905 IMP located_in clathrin-coated pit 25898166 Component
8301 GO:0009986 IDA located_in cell surface 26005850 Component
8301 GO:0016020 HDA located_in membrane 19946888 Component
8301 GO:0030132 IDA part_of clathrin coat of coated pit 10436022,16262731 Component
8301 GO:0030136 IMP located_in clathrin-coated vesicle 25898166 Component
8301 GO:0043025 IDA located_in neuronal cell body 23589030 Component
8301 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
8301 GO:0070381 IDA located_in endosome to plasma membrane transport vesicle 26005850 Component
8301 GO:0097418 IMP located_in neurofibrillary tangle 23589030 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8301 GO:0006879 IMP involved_in intracellular iron ion homeostasis 22952941 Process
8301 GO:0006897 IDA involved_in endocytosis 22118466 Process
8301 GO:0006898 IDA involved_in receptor-mediated endocytosis 10436022 Process
8301 GO:0006900 IMP involved_in vesicle budding from membrane 25898166 Process
8301 GO:0010629 IMP involved_in negative regulation of gene expression 22952941 Process
8301 GO:0016197 IMP involved_in endosomal transport 16262731 Process
8301 GO:0030100 IMP involved_in regulation of endocytosis 18182011 Process
8301 GO:0031623 IMP involved_in receptor internalization 14985334,25898166 Process
8301 GO:0032880 IDA involved_in regulation of protein localization 10436022 Process
8301 GO:0035459 IMP involved_in vesicle cargo loading 24577224 Process
8301 GO:0043547 IMP involved_in positive regulation of GTPase activity 26005850 Process
8301 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 11425879 Process
8301 GO:0048261 IDA involved_in negative regulation of receptor-mediated endocytosis 10436022 Process
8301 GO:0048268 IDA involved_in clathrin coat assembly 16262731 Process
8301 GO:0048268 IMP involved_in clathrin coat assembly 16262731 Process
8301 GO:0060586 IMP involved_in multicellular organismal-level iron ion homeostasis 22952941 Process
8301 GO:0072583 IMP involved_in clathrin-dependent endocytosis 22952941,24577224,26005850 Process
8301 GO:0097494 IMP involved_in regulation of vesicle size 25898166 Process
8301 GO:0097753 IMP involved_in membrane bending 25898166 Process
8301 GO:0150093 IGI involved_in amyloid-beta clearance by transcytosis 26005850 Process
8301 GO:1902004 IMP involved_in positive regulation of amyloid-beta formation 24577224 Process
8301 GO:1902959 IMP involved_in regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 24577224 Process
8301 GO:1903077 IMP involved_in negative regulation of protein localization to plasma membrane 21221849 Process
8301 GO:2000009 IMP involved_in negative regulation of protein localization to cell surface 21221849 Process