Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 834
  • Symbol: CASP1
  • Description: caspase 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
834 GO:0004175 IDA enables endopeptidase activity 24548080 Function
834 GO:0004197 IDA enables cysteine-type endopeptidase activity 1574116,2787508,11821383,15326478,16920334,22464733,32109412,3..... Function
834 GO:0004197 IGI enables cysteine-type endopeptidase activity 15882992 Function
834 GO:0005515 IPI enables protein binding 11374873,11390368,11432859,11536016,12888622,15030775,15107016..... Function
834 GO:0019900 IPI enables kinase binding 11432859,11536016,15383541 Function
834 GO:0042802 IMP enables identical protein binding 11432859 Function
834 GO:0042802 IPI enables identical protein binding 24630722,27043298 Function
834 GO:0050700 IPI enables CARD domain binding 11821383,16920334 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
834 GO:0005737 IDA is_active_in cytoplasm 20197547 Component
834 GO:0005829 IDA is_active_in cytosol 20197547 Component
834 GO:0032991 IDA part_of protein-containing complex 16920334 Component
834 GO:0032991 IMP part_of protein-containing complex 11536016,11821383,15383541 Component
834 GO:0061702 IPI part_of canonical inflammasome complex 16037825 Component
834 GO:0072558 IDA part_of NLRP1 inflammasome complex 12191486 Component
834 GO:0072558 IPI part_of NLRP1 inflammasome complex 17349957 Component
834 GO:0072559 IDA part_of NLRP3 inflammasome complex 15030775 Component
834 GO:0072559 IPI part_of NLRP3 inflammasome complex 29255148 Component
834 GO:0097169 IDA part_of AIM2 inflammasome complex 19158676 Component
834 GO:0097169 IPI part_of AIM2 inflammasome complex 24630722 Component
834 GO:0097179 IMP part_of protease inhibitor complex 11432859 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
834 GO:0006508 IDA involved_in proteolysis 12888622,24548080 Process
834 GO:0016540 IDA involved_in protein autoprocessing 11821383,32109412 Process
834 GO:0032731 IDA involved_in positive regulation of interleukin-1 beta production 7642516,11432859,11821383,15326478,16037825,24630722..... Process
834 GO:0032731 IMP involved_in positive regulation of interleukin-1 beta production 11536016,22267217 Process
834 GO:0032741 IDA involved_in positive regulation of interleukin-18 production 15326478 Process
834 GO:0043123 IEP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 12761501 Process
834 GO:0043123 IMP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 15383541 Process
834 GO:0043280 IMP involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 16920334 Process
834 GO:0050727 IDA involved_in regulation of inflammatory response 32109412,32553275 Process
834 GO:0050729 IDA involved_in positive regulation of inflammatory response 12191486,15326478,32109412,32553275 Process
834 GO:0051604 IDA involved_in protein maturation 15326478,22464733,32109412,32553275 Process
834 GO:0070269 IDA involved_in pyroptosis 32109412,32553275 Process
834 GO:0071222 IDA involved_in cellular response to lipopolysaccharide 22464733 Process
834 GO:0071222 IMP involved_in cellular response to lipopolysaccharide 11536016 Process
834 GO:0071260 IEP involved_in cellular response to mechanical stimulus 19593445 Process
834 GO:0071310 IDA acts_upstream_of_or_within cellular response to organic substance 19158679 Process
834 GO:0071346 IMP involved_in cellular response to type II interferon 11536016 Process
834 GO:0140447 IGI involved_in cytokine precursor processing 15882992 Process
834 GO:0140448 IGI involved_in signaling receptor ligand precursor processing 15882992 Process
834 GO:0140970 IDA involved_in AIM2 inflammasome complex assembly 19158675 Process
834 GO:1903265 IMP involved_in positive regulation of tumor necrosis factor-mediated signaling pathway 16920334 Process