Gene Ontology

Gene Info

• Species: Yeast (Saccharomyces cerevisiae)
• GeneID: 851520
• Symbol: SIR2
• Description: NAD-dependent histone deacetylase SIR2

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
851520	GO:0000183	IMP	involved_in	rDNA heterochromatin formation	2647300	Process
851520	GO:0006303	IMP	involved_in	double-strand break repair via nonhomologous end joining	9501103	Process
851520	GO:0006325	IDA	involved_in	chromatin organization	11553718	Process
851520	GO:0006325	IGI	involved_in	chromatin organization	26951198	Process
851520	GO:0007062	IMP	involved_in	sister chromatid cohesion	27185881	Process
851520	GO:0008156	IMP	involved_in	negative regulation of DNA replication	15082529	Process
851520	GO:0030466	IMP	involved_in	silent mating-type cassette heterochromatin formation	3297920,11950950	Process
851520	GO:0031494	IMP	involved_in	regulation of mating type switching	31461456	Process
851520	GO:0031509	IMP	involved_in	subtelomeric heterochromatin formation	1913809,9501103,11950950	Process
851520	GO:0034398	IMP	involved_in	telomere tethering at nuclear periphery	27122604	Process
851520	GO:0045910	IGI	involved_in	negative regulation of DNA recombination	16182251	Process
851520	GO:0045910	IMP	involved_in	negative regulation of DNA recombination	25822194	Process
851520	GO:0097695	IMP	involved_in	establishment of protein-containing complex localization to telomere	26218225	Process
851520	GO:0097752	IMP	involved_in	regulation of DNA stability	27820830	Process
851520	GO:1904524	IMP	involved_in	negative regulation of DNA amplification	26195783	Process

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
851520	GO:0000781	IDA	located_in	chromosome, telomeric region	9710643	Component
851520	GO:0000781	IMP	located_in	chromosome, telomeric region	27122604	Component
851520	GO:0000792	IDA	part_of	heterochromatin	20176978	Component
851520	GO:0005677	IDA	part_of	chromatin silencing complex	9122169	Component
851520	GO:0005730	IDA	located_in	nucleolus	9214640	Component
851520	GO:0030869	IDA	part_of	RENT complex	10219244	Component

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
851520	GO:0003688	IDA	enables	DNA replication origin binding	29795547	Function
851520	GO:0017136	IDA	enables	NAD-dependent histone deacetylase activity	10811920	Function
851520	GO:0031491	IDA	contributes_to	nucleosome binding	19217406	Function
851520	GO:0032041	IDA	enables	NAD-dependent histone H3K14 deacetylase activity	10693811	Function
851520	GO:0046969	IDA	enables	NAD-dependent histone H3K9 deacetylase activity	10693811	Function
851520	GO:0046970	IDA	enables	NAD-dependent histone H4K16 deacetylase activity	10693811	Function