Gene Ontology

Gene Info

• Species: Yeast (Saccharomyces cerevisiae)
• GeneID: 854138
• Symbol: DIS3
• Description: exosome catalytic subunit DIS3

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
854138	GO:0000049	IDA	enables	tRNA binding	17643380	Function
854138	GO:0000049	IMP	enables	tRNA binding	17643380	Function
854138	GO:0000175	IDA	enables	3'-5'-RNA exonuclease activity	17173052,17643380	Function
854138	GO:0000175	IMP	enables	3'-5'-RNA exonuclease activity	17173052,17643380	Function
854138	GO:0004521	IDA	enables	RNA endonuclease activity	19060886,19060898,19129231	Function
854138	GO:0004521	IMP	enables	RNA endonuclease activity	19060886,19129231	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
854138	GO:0000176	IDA	part_of	nuclear exosome (RNase complex)	10465791,19046973	Component
854138	GO:0000177	IDA	part_of	cytoplasmic exosome (RNase complex)	10465791,19046973	Component
854138	GO:0005634	HDA	located_in	nucleus	22842922	Component
854138	GO:0005730	HDA	located_in	nucleolus	22842922	Component
854138	GO:0005730	IDA	located_in	nucleolus	9562621	Component
854138	GO:0005739	HDA	located_in	mitochondrion	14576278,16823961	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
854138	GO:0000467	IMP	involved_in	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9390555,10508172	Process
854138	GO:0006397	IMP	involved_in	mRNA processing	27385342	Process
854138	GO:0016075	IMP	involved_in	rRNA catabolic process	10508172	Process
854138	GO:0043628	IMP	involved_in	regulatory ncRNA 3'-end processing	11352936	Process
854138	GO:0070651	IMP	involved_in	nonfunctional rRNA decay	19481524	Process
854138	GO:0071028	IMP	involved_in	nuclear mRNA surveillance	11030620	Process
854138	GO:0071035	IMP	involved_in	nuclear polyadenylation-dependent rRNA catabolic process	16431988,18940861	Process
854138	GO:0071038	IDA	involved_in	nuclear polyadenylation-dependent tRNA catabolic process	15828860,15935758,17643380	Process
854138	GO:0071038	IGI	involved_in	nuclear polyadenylation-dependent tRNA catabolic process	15145828	Process
854138	GO:0071038	IMP	involved_in	nuclear polyadenylation-dependent tRNA catabolic process	17643380	Process
854138	GO:0071039	IMP	involved_in	nuclear polyadenylation-dependent CUT catabolic process	15935759	Process