Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 8878
  • Symbol: SQSTM1
  • Description: sequestosome 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8878 GO:0000423 IGI involved_in mitophagy 20457763 Process
8878 GO:0000425 IDA involved_in pexophagy 26344566 Process
8878 GO:0006914 IDA involved_in autophagy 20452972 Process
8878 GO:0006914 IMP involved_in autophagy 17580304 Process
8878 GO:0007032 IDA involved_in endosome organization 27368102 Process
8878 GO:0010508 IDA involved_in positive regulation of autophagy 28871090 Process
8878 GO:0016236 IMP involved_in macroautophagy 20168092 Process
8878 GO:0030163 IDA involved_in protein catabolic process 27498865,30612879,32715615,36221902 Process
8878 GO:0031397 IDA involved_in negative regulation of protein ubiquitination 20452972 Process
8878 GO:0034614 IDA involved_in cellular response to reactive oxygen species 26344566 Process
8878 GO:0035973 IPI involved_in aggrephagy 28404643 Process
8878 GO:0043122 IMP involved_in regulation of I-kappaB kinase/NF-kappaB signaling 12857745 Process
8878 GO:0061635 IDA involved_in regulation of protein complex stability 25127057 Process
8878 GO:0061912 IDA involved_in selective autophagy 27498865,30612879,32715615,36221902 Process
8878 GO:0061912 IMP involved_in selective autophagy 22622177 Process
8878 GO:0071211 IDA involved_in protein targeting to vacuole involved in autophagy 27498865,30612879,32715615,36221902 Process
8878 GO:0098780 IGI involved_in response to mitochondrial depolarisation 20457763 Process
8878 GO:1905719 IDA involved_in protein localization to perinuclear region of cytoplasm 27368102 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8878 GO:0000932 IDA located_in P-body 20357094 Component
8878 GO:0005737 IDA located_in cytoplasm 20168092 Component
8878 GO:0005776 IDA is_active_in autophagosome 30612879 Component
8878 GO:0005776 IDA located_in autophagosome 17580304,19640926,20168092,22948227,24954904 Component
8878 GO:0005829 IDA located_in cytosol Component
8878 GO:0016234 IDA located_in inclusion body 20168092 Component
8878 GO:0016605 IDA located_in PML body 20168092 Component
8878 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
8878 GO:0044753 IDA located_in amphisome 19640926 Component
8878 GO:0044754 IDA located_in autolysosome 19640926 Component
8878 GO:0070062 HDA located_in extracellular exosome 19056867 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8878 GO:0005080 IPI enables protein kinase C binding 14676191 Function
8878 GO:0005515 IPI enables protein binding 8618896,8702753,14676191,16169070,16189514,16874300,17389358,1..... Function
8878 GO:0019899 IPI enables enzyme binding 27368102 Function
8878 GO:0019901 IDA enables protein kinase binding 8650207 Function
8878 GO:0030674 IDA enables protein-macromolecule adaptor activity 26344566 Function
8878 GO:0031625 IDA enables ubiquitin protein ligase binding 27368102 Function
8878 GO:0031625 IPI enables ubiquitin protein ligase binding 25127057,27368102 Function
8878 GO:0035591 IDA enables signaling adaptor activity 27498865,30612879,32715615,36221902 Function
8878 GO:0038023 IDA enables signaling receptor activity 28871090 Function
8878 GO:0042169 IDA enables SH2 domain binding 8650207 Function
8878 GO:0042802 IPI enables identical protein binding 16169070,20562859,21900206,25416956,25686248,32296183..... Function
8878 GO:0043130 IDA enables ubiquitin binding 12857745 Function
8878 GO:0070530 IDA enables K63-linked polyubiquitin modification-dependent protein binding 28404643,36221902 Function
8878 GO:0140036 IDA enables ubiquitin-dependent protein binding 26344566,27498865 Function