Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 93759
  • Symbol: Sirt1
  • Description: sirtuin 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
93759 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 19470756 Process
93759 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 20955178 Process
93759 GO:0000720 IMP involved_in pyrimidine dimer repair by nucleotide-excision repair 21149730 Process
93759 GO:0000731 IMP involved_in DNA synthesis involved in DNA repair 17612497 Process
93759 GO:0001525 IMP involved_in angiogenesis 22315447 Process
93759 GO:0001542 IMP acts_upstream_of_or_within ovulation from ovarian follicle 12482959 Process
93759 GO:0001678 IMP involved_in intracellular glucose homeostasis 15744310 Process
93759 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 17901049 Process
93759 GO:0006476 IDA acts_upstream_of_or_within protein deacetylation 22514318 Process
93759 GO:0006476 IDA involved_in protein deacetylation 11672523 Process
93759 GO:0006476 IMP involved_in protein deacetylation 17521387,18662546,19470756 Process
93759 GO:0006642 IMP involved_in triglyceride mobilization 15175761 Process
93759 GO:0007283 IMP acts_upstream_of_or_within spermatogenesis 12482959 Process
93759 GO:0007623 IEP involved_in circadian rhythm 18662546 Process
93759 GO:0008630 IDA involved_in intrinsic apoptotic signaling pathway in response to DNA damage 16269335 Process
93759 GO:0009267 IMP involved_in cellular response to starvation 15175761 Process
93759 GO:0010875 IMP involved_in positive regulation of cholesterol efflux 17936707 Process
93759 GO:0010883 IMP involved_in regulation of lipid storage 22315447 Process
93759 GO:0010906 IMP involved_in regulation of glucose metabolic process 17347648 Process
93759 GO:0014068 IMP involved_in positive regulation of phosphatidylinositol 3-kinase signaling 20620997 Process
93759 GO:0016239 IDA involved_in positive regulation of macroautophagy 18296641,21189328 Process
93759 GO:0030225 IMP involved_in macrophage differentiation 22315447 Process
93759 GO:0030512 IDA involved_in negative regulation of transforming growth factor beta receptor signaling pathway 17098745 Process
93759 GO:0031393 IMP involved_in negative regulation of prostaglandin biosynthetic process 20042607 Process
93759 GO:0031507 IGI acts_upstream_of_or_within heterochromatin formation 23160044 Process
93759 GO:0031648 IDA involved_in protein destabilization 17936707 Process
93759 GO:0032007 IMP involved_in negative regulation of TOR signaling 20169165 Process
93759 GO:0032868 IDA involved_in response to insulin 17901049 Process
93759 GO:0032922 IMP involved_in circadian regulation of gene expression 18662546,19299583 Process
93759 GO:0033210 IMP involved_in leptin-mediated signaling pathway 20620997 Process
93759 GO:0034391 IDA involved_in regulation of smooth muscle cell apoptotic process 17098745 Process
93759 GO:0035356 IMP involved_in intracellular triglyceride homeostasis 17936707 Process
93759 GO:0035358 IMP involved_in regulation of peroxisome proliferator activated receptor signaling pathway 15175761 Process
93759 GO:0042326 IMP involved_in negative regulation of phosphorylation 17612497 Process
93759 GO:0042595 IMP acts_upstream_of_or_within behavioral response to starvation 20668205 Process
93759 GO:0042632 IMP involved_in cholesterol homeostasis 17936707 Process
93759 GO:0043065 IMP involved_in positive regulation of apoptotic process 20167603 Process
93759 GO:0043433 IMP involved_in negative regulation of DNA-binding transcription factor activity 20955178 Process
93759 GO:0043524 IGI acts_upstream_of_or_within negative regulation of neuron apoptotic process 22956852 Process
93759 GO:0044321 IMP involved_in response to leptin 20620997 Process
93759 GO:0045599 IMP involved_in negative regulation of fat cell differentiation 15175761 Process
93759 GO:0045722 IMP involved_in positive regulation of gluconeogenesis 26168293 Process
93759 GO:0045892 IDA acts_upstream_of_or_within negative regulation of DNA-templated transcription 15381699 Process
93759 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 15220471,25526086 Process
93759 GO:0050872 IMP involved_in white fat cell differentiation 15175761 Process
93759 GO:0051152 IMP involved_in positive regulation of smooth muscle cell differentiation 25526086 Process
93759 GO:0051898 IMP involved_in negative regulation of protein kinase B signaling 21149730 Process
93759 GO:0055089 IMP involved_in fatty acid homeostasis 17347648 Process
93759 GO:0060907 IMP involved_in positive regulation of macrophage cytokine production 22315447 Process
93759 GO:0070857 IMP involved_in regulation of bile acid biosynthetic process 20375098 Process
93759 GO:0071479 IMP involved_in cellular response to ionizing radiation 17612497 Process
93759 GO:0090335 IMP involved_in regulation of brown fat cell differentiation 20620997 Process
93759 GO:0106230 IDA involved_in protein depropionylation 30026585 Process
93759 GO:1900113 IDA involved_in negative regulation of histone H3-K9 trimethylation 25526086 Process
93759 GO:1902166 IMP involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 11672522 Process
93759 GO:1902237 IMP involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 20955178 Process
93759 GO:1904179 IMP involved_in positive regulation of adipose tissue development 22315447 Process
93759 GO:1990830 IEP acts_upstream_of_or_within cellular response to leukemia inhibitory factor 20439489 Process
93759 GO:2000111 IMP involved_in positive regulation of macrophage apoptotic process 20042607 Process
93759 GO:2000481 IDA involved_in positive regulation of cAMP-dependent protein kinase activity 18687677 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
93759 GO:0000785 IDA part_of chromatin 16269335 Component
93759 GO:0000792 IDA part_of heterochromatin 18004385 Component
93759 GO:0005634 IDA located_in nucleus 12482959,15381699,18004385,18662546,19470756,22514318..... Component
93759 GO:0005737 IDA located_in cytoplasm 17197703,17521387,19470756 Component
93759 GO:0005739 IDA located_in mitochondrion 26767982 Component
93759 GO:0032991 IDA part_of protein-containing complex 22514318 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
93759 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 19299583 Function
93759 GO:0002039 IPI enables p53 binding 11672522 Function
93759 GO:0003713 IDA enables transcription coactivator activity 25526086 Function
93759 GO:0003714 IMP enables transcription corepressor activity 15175761 Function
93759 GO:0005515 IPI enables protein binding 11672523,15175761,15220471,15716268,15744310,16269335,16892051..... Function
93759 GO:0017136 IDA enables NAD-dependent histone deacetylase activity 10693811 Function
93759 GO:0019213 IMP enables deacetylase activity 18004385 Function
93759 GO:0019899 IPI enables enzyme binding 19578370,20972425 Function
93759 GO:0019904 IPI enables protein domain specific binding 15175761 Function
93759 GO:0033558 IDA enables protein lysine deacetylase activity 19578370 Function
93759 GO:0033558 IMP enables protein lysine deacetylase activity 17521387,20167603,24089055 Function
93759 GO:0034979 EXP enables NAD-dependent protein deacetylase activity 11250901 Function
93759 GO:0034979 IDA enables NAD-dependent protein deacetylase activity 11672523,15220471,15716268,16790548 Function
93759 GO:0046969 IDA enables NAD-dependent histone H3K9 deacetylase activity 20972425 Function
93759 GO:0106231 IMP enables protein-propionyllysine depropionylase activity 30026585 Function
93759 GO:1990841 IDA enables promoter-specific chromatin binding 22514318 Function