Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 9693
  • Symbol: RAPGEF2
  • Description: Rap guanine nucleotide exchange factor 2

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9693 GO:0005085 IDA enables guanyl-nucleotide exchange factor activity 10608883,10801446,12391161,16272156 Function
9693 GO:0005096 IDA enables GTPase activator activity 10934204 Function
9693 GO:0005515 IPI enables protein binding 10548487,10608844,11168587,11359771,11598133,12391161,23885123..... Function
9693 GO:0030165 IDA enables PDZ domain binding 10548487,11168587,12391161 Function
9693 GO:0030552 IDA NOT enables cAMP binding 10548487,10608844,11359771 Function
9693 GO:0030552 IDA enables cAMP binding 10801446 Function
9693 GO:0030553 IDA NOT enables cGMP binding 10608844,11359771 Function
9693 GO:0031697 IDA enables beta-1 adrenergic receptor binding 12391161 Function
9693 GO:0050699 IDA enables WW domain binding 10548487,11598133 Function
9693 GO:0070300 IDA enables phosphatidic acid binding 22797597 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9693 GO:0005737 IDA located_in cytoplasm 11359771,17724123 Component
9693 GO:0005770 IDA located_in late endosome 17724123 Component
9693 GO:0005829 IDA located_in cytosol 22797597 Component
9693 GO:0005886 IDA located_in plasma membrane Component
9693 GO:0005923 IDA located_in bicellular tight junction 23885123 Component
9693 GO:0016020 IDA located_in membrane 10608883 Component
9693 GO:0016324 IDA located_in apical plasma membrane 22797597 Component
9693 GO:0030139 IDA located_in endocytic vesicle 22797597 Component
9693 GO:0048471 IDA located_in perinuclear region of cytoplasm 11359771 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9693 GO:0007186 IDA involved_in G protein-coupled receptor signaling pathway 23800469 Process
9693 GO:0007218 IDA involved_in neuropeptide signaling pathway 23800469 Process
9693 GO:0008285 IDA involved_in negative regulation of cell population proliferation 16272156 Process
9693 GO:0019933 IDA involved_in cAMP-mediated signaling 23800469 Process
9693 GO:0030033 IGI involved_in microvillus assembly 22797597 Process
9693 GO:0031175 IDA involved_in neuron projection development 23800469 Process
9693 GO:0032486 IMP involved_in Rap protein signal transduction 21840392 Process
9693 GO:0043547 IDA involved_in positive regulation of GTPase activity 10548487,10608844,10801446,11359771,16272156,17724123,23800469..... Process
9693 GO:0043547 IMP involved_in positive regulation of GTPase activity 21840392,22797597 Process
9693 GO:0043950 IDA involved_in positive regulation of cAMP-mediated signaling 12391161 Process
9693 GO:0045860 IDA involved_in positive regulation of protein kinase activity 11359771,23800469 Process
9693 GO:0050774 IDA involved_in negative regulation of dendrite morphogenesis 16272156 Process
9693 GO:0061028 IMP involved_in establishment of endothelial barrier 21840392 Process
9693 GO:0070374 IDA involved_in positive regulation of ERK1 and ERK2 cascade 16272156,23800469 Process
9693 GO:0071320 IDA involved_in cellular response to cAMP 10801446,16272156,21840392,23800469 Process
9693 GO:0071321 IDA involved_in cellular response to cGMP 10801446 Process
9693 GO:0071880 IDA involved_in adenylate cyclase-activating adrenergic receptor signaling pathway 12391161 Process
9693 GO:0072659 IMP involved_in protein localization to plasma membrane 22797597 Process
9693 GO:0090557 IMP involved_in establishment of endothelial intestinal barrier 23885123 Process
9693 GO:1901888 IMP involved_in regulation of cell junction assembly 21840392 Process
9693 GO:2000481 IDA involved_in positive regulation of cAMP-dependent protein kinase activity 16272156 Process
9693 GO:2000670 IDA involved_in positive regulation of dendritic cell apoptotic process 16272156 Process