| 100206 |
Q8CG72 |
ADPRS_MOUSE |
ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protei |
DISRUPTION PHENOTYPE |
Knockout mice are phenotypically normal and fertile (PubMed:30830864). 1 hour induced brain ischemia results in 100% fatality within 24 hours (PubMed:30830864). 30 minutes of induced brain ischemia results in an increase in infarct size in the cortex, hippocampus, and striatum (PubMed:30830864). Increased number of cortical neurons with nucleus-accumulated poly(ADP-ribose) and higher abundance of poly(ADP-ribose) in general (PubMed:30830864). {ECO:0000269|PubMed:30830864}. |