| 103988 |
P52792 |
HXK4_MOUSE |
Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D) |
DISRUPTION PHENOTYPE |
Embryonic lethality caused by the absence of hexokinase activity (PubMed:7665557). Conditional deletion in pancreatic beta-cells causes severe diabetes shortly after birth leading to lethality within a week (PubMed:8530440, PubMed:9867845). Deficient islets show defective insulin secretion in response to glucose (PubMed:8530440). Conditional deletion in liver leads to mild hyperglycemia; however, mice display pronounced defects in both glycogen synthesis and glucose turnover rates during a hyperglycemic clamp (PubMed:9867845). {ECO:0000269|PubMed:7665557, ECO:0000269|PubMed:8530440, ECO:0000269|PubMed:9867845}. |