| 108072 |
Q5NCH9 |
GRM6_MOUSE |
Metabotropic glutamate receptor 6 (mGluR6) |
DISRUPTION PHENOTYPE |
Retinal cells from mutant mice display a subtly altered response to cycles of light and darkness, due to a failure of the ON bipolar cells in the retina to become depolarized in response to light. As a consequence, mutant mice display little or no pupillary contraction in adaptation to low light intensity. Besides, they exhibit strongly impaired responses to moving stimuli, and fail to produce a response when the visual constrast is low. Besides, rod bipolar cells from mutant mice lack TRPM1 channel activity. {ECO:0000269|PubMed:22131384, ECO:0000269|PubMed:7889569, ECO:0000269|PubMed:9144650}. |