Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 110197
  • Symbol: Dgkg
  • Description: diacylglycerol kinase, gamma
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Gene ID Entry Entry Name Protein Name Type Information
110197 Q91WG7 DGKG_MOUSE Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (88 kDa diacylglycerol kinase) (Diglyceride kinase gamma) (DGK-gamma) DISRUPTION PHENOTYPE Homozygous knockout mice show impairments in motor coordination, long-term depression/LTD and development of Purkinje cells (PubMed:32033984). The level of phosphatidic acid in synaptosomal membranes is significantly decreased (PubMed:32033984). The number of branches, the total length of the dendrites and the membrane capacitance of the distal dendritic region are significantly lower (PubMed:32033984). {ECO:0000269|PubMed:32033984}.