| 11364 |
P45952 |
ACADM_MOUSE |
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) |
DISRUPTION PHENOTYPE |
Mice lacking Mcad show increased neonatal mortality (PubMed:16121256). They display hypothermia and cold intolerance upon fasting (PubMed:16121256). Their serum and bile acylcarnitine profile is also different from wild-type mice, with an elevation of serum decenoylcarnitine compared to wild-type mice (PubMed:16121256). They also display hepatic steatosis following fast periods (PubMed:16121256). They develop significantly elevated concentrations of urinary adipic, suberic, and sebacic acids and hexanoylglycine (PubMed:16121256). {ECO:0000269|PubMed:16121256}. |