| 11757 |
P20108 |
PRDX3_MOUSE |
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (PRX III) (Perioredoxin-3) (Protein MER5) (Thioredoxin-dependent peroxiredoxin 3) |
DISRUPTION PHENOTYPE |
Accelerates decline of physical strength; at the age of 10 months, the physical strength is much lower than in the wild-type littermate (PubMed:27037278). Increased oxidative damage and decreased mitochondrial DNA copy number in skeletal muscles (PubMed:27037278). Increased apoptotic cells in the brain (PubMed:27037278). {ECO:0000269|PubMed:27037278}. |