Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 12488
  • Symbol: Cd2ap
  • Description: CD2-associated protein
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Gene ID Entry Entry Name Protein Name Type Information
12488 Q9JLQ0 CD2AP_MOUSE CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1) DISRUPTION PHENOTYPE Death at 6 to 7 weeks of age from renal failure. Mice show defects in epithelial foot processes, accompanied by mesangial cell hyperplasia and extracellular matrix deposition. {ECO:0000269|PubMed:10514378}.