| 13405 |
P11531 |
DMD_MOUSE |
Dystrophin |
DISRUPTION PHENOTYPE |
Mutant mice show reduced contractile force compared to wild-types, at least for soleus muscle. They have decreased motor activity levels after exercise, increased muscle permeability and fibrosis with impaired regeneration (PubMed:28498977). MEGF10 and DMD double knockout animals have pronounced fiber size variability and intracellular inclusions in the quadriceps femoris with extensive endomysial connective tissue infiltration. Mice develop muscle weakness, kyphosis and a waddling gait. At 2 months of age, they have reduced contractile force compared to wild-type mice. They display reduced motor activity after exercise and they walk shorter distances than wild-type. They have a delayed regeneration after muscle injury and an aberrant muscle fiber typing and cross-sectional areas (PubMed:28498977). {ECO:0000269|PubMed:28498977}. |