Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 13869
  • Symbol: Erbb4
  • Description: erb-b2 receptor tyrosine kinase 4
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Gene ID Entry Entry Name Protein Name Type Information
13869 Q61527 ERBB4_MOUSE Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] DISRUPTION PHENOTYPE Embryonically lethal. Embryos die at about 10 dpc, due to defects in the development of myocardial trabeculae in the heart ventricle that lead to severely reduced embryonic blood flow. Mice also display aberrant innervation from and to the hindbrain, especially concerning the trigeminal, facial and acoustic ganglia. This is due to aberrant migration of a subpopulation of cranial neural crest cells. {ECO:0000269|PubMed:10655590, ECO:0000269|PubMed:12824469, ECO:0000269|PubMed:12954715, ECO:0000269|PubMed:7477376}.