| 16443 |
Q9Z0R4 |
ITSN1_MOUSE |
Intersectin-1 (EH and SH3 domains protein 1) |
DISRUPTION PHENOTYPE |
No visible phenotype, except that about 13% of the pups do not thrive. Mice are born at the expected Mendelian rate (PubMed:18676989). Mutant mice display no obvious defects in synaptic responses to single stimuli at the calyx of Held. Repetitive stimulation gives rise to decreased synaptic responses, due to perturbation of the replenishment of release-ready synaptic vesicles (PubMed:23633571). {ECO:0000269|PubMed:18676989, ECO:0000269|PubMed:23633571}. |