| 17250 |
O35379 |
MRP1_MOUSE |
Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) |
DISRUPTION PHENOTYPE |
Homozygous ABCC1 knockout mice are healthy and fertile up to at least 12 months of age. They are hypersensitive to anticancer drugs resulting in an increased loss of body weight and mortality and have a decreased inflammatory response. {ECO:0000269|PubMed:9359705}. |