| 17260 |
Q8CFN5 |
MEF2C_MOUSE |
Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) |
DISRUPTION PHENOTYPE |
Mice show impairment in hippocampal-dependent learning and also increase in the number of excitatory synapses and potentiation of basal and evoked synaptic transmission. Mice surviving to adulthood manifest smaller, apparently less mature neurons and smaller whole brain size, with resultant aberrant electrophysiology and behavior. Mice exhibit thrombocytopenia and a defect in B-lymphopoiesis. {ECO:0000269|PubMed:18599437, ECO:0000269|PubMed:18599438, ECO:0000269|PubMed:19211936}. |