| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 17283 | O88559 | MEN1_MOUSE | Menin | DISRUPTION PHENOTYPE | Homozygous mice die in utero at 11.5-12.5 dpc. At 9 months of age, heterozygous mice develop pancreatic islet lesions, from hyperplasia to insulin-producing islet cell tumors, and frequently parathyroid adenomas. Larger, more numerous tumors involving pancreatic islets, parathyroids, thyroid, adrenal cortex and pituitary are seen by 16 months. All tumors show loss of the wild-type allele. {ECO:0000269|PubMed:11158604}. |
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