Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 18391
  • Symbol: Sigmar1
  • Description: sigma non-opioid intracellular receptor 1
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Gene ID Entry Entry Name Protein Name Type Information
18391 O55242 SGMR1_MOUSE Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R) DISRUPTION PHENOTYPE Mice display decreased hypermotility response induced by (+)SKF-10047 challenge and reduced formalin-induced pain (PubMed:14622179). Mice display motor coordination defects, muscle weakness, partial neuromuscular junction innervation, and motor neuron degeneration (PubMed:20167253, PubMed:25678561). {ECO:0000269|PubMed:14622179, ECO:0000269|PubMed:20167253, ECO:0000269|PubMed:25678561}.