| 192167 |
Q99K10 |
NLGN1_MOUSE |
Neuroligin-1 |
DISRUPTION PHENOTYPE |
No obvious phenotype, but mice present subtle behavorial changes with some deficits in spatial learning and memory. In addition, mice have reduced brain volume. Mice lacking both NLGN1 and NLGN2, or NLGN1 and NLGN3, are viable, but have impaired breathing, drastically reduced reproduction rates and striking deficits in raising their offspring. Mice lacking NLGN1, NLGN2 and NLGN3 are born at the expected Mendelian rate, but die shortly after birth due to respiratory failure. They do not show a significant change in the number of synapses, but synapse function is strongly impaired. Mice exhibit social novelty and fear-conditioning deficits and also show reduced wakefulness duration and altered EEG during wakefulness and sleep. {ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:20147539, ECO:0000269|PubMed:23716671}. |