| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 19247 | P35235 | PTN11_MOUSE | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2) | DISRUPTION PHENOTYPE | Conditional deletion in limb and head mesenchyme leads to increased cartilage mass and deficient ossification: osteochondroprogenitors become chondrocytes and not osteoblasts caused by inability of PTPN11/SHP2 to mediate tyrosine dephosphorylation of SOX9. {ECO:0000269|PubMed:29644115}. |
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