Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 192663
  • Symbol: Abcg4
  • Description: ATP binding cassette subfamily G member 4
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Gene ID Entry Entry Name Protein Name Type Information
192663 Q91WA9 ABCG4_MOUSE ATP-binding cassette subfamily G member 4 (EC 7.6.2.-) (ATP-binding cassette transporter White2) DISRUPTION PHENOTYPE Abcg4 deficiency does not significantly affect the levels of sterols in the brain except for brain lathosterol levels, which are slightly elevated (PubMed:18039927). Abcg1/Abcg4 double knockout mice display significant accumulation of 24(S)-hydroxycholesterol (24S-HC) and 27-hydroxy-cholesterol (27-HC) in addition to the cholesterol synthesis intermediates, desmosterol, lanosterol and lathosterol (PubMed:19633360, PubMed:18039927). {ECO:0000269|PubMed:18039927, ECO:0000269|PubMed:19633360}.