Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 20191
  • Symbol: Ryr2
  • Description: ryanodine receptor 2, cardiac
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Gene ID Entry Entry Name Protein Name Type Information
20191 E9Q401 RYR2_MOUSE Ryanodine receptor 2 (RYR-2) (RyR2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) DISRUPTION PHENOTYPE Embryonically lethal. Embryos die at about 10 dpc, due to defects in heart tube development. Cardiac myotubes display enlarged rough endoplasmic reticulum and cytoplasmic vesicles that contain high levels of Ca(2+). {ECO:0000269|PubMed:9628868}.