Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 20198
  • Symbol: S100a4
  • Description: S100 calcium binding protein A4
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Gene ID Entry Entry Name Protein Name Type Information
20198 P07091 S10A4_MOUSE Protein S100-A4 (Metastasin) (Metastatic cell protein) (PEL98) (Placental calcium-binding protein) (Protein 18A2) (Protein Mts1) (S100 calcium-binding protein A4) DISRUPTION PHENOTYPE Deletion mice are fertile, grow normally and exhibit no overt abnormalities; however loss of S100A4 results in impaired recruitment of macrophages to sites of inflammation in vivo (PubMed:20519440). Mice also show decreased metastatic burden in lungs of PyMT-induced mammary tumors which is associated with reduced vessel density (PubMed:20103644). {ECO:0000269|PubMed:20103644, ECO:0000269|PubMed:20519440}.