Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 20430
  • Symbol: Cyfip1
  • Description: cytoplasmic FMR1 interacting protein 1
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Gene ID Entry Entry Name Protein Name Type Information
20430 Q7TMB8 CYFP1_MOUSE Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) DISRUPTION PHENOTYPE Mice display greatly reduced lamellipodium formation in response to growth factor stimulation or aluminum fluoride treatment. Abnormal epithelial morphogenesis in vitro, and cooperation with oncogenic Ras to produce invasive carcinomas in vivo. {ECO:0000269|PubMed:14765121, ECO:0000269|PubMed:19524508}.